Outcome of Diffuse Large B-Cell Lymphoma with First-line Chemotherapy

Haematology Journal of Bangladesh

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Title Outcome of Diffuse Large B-Cell Lymphoma with First-line Chemotherapy
Creator Chowdhury, Zulfia Zinat
Bahar, Tamanna
Rahman, Shaila
Haque, Salina
Islam, A K M Mynul
Ali, Mohammad
Rahman, Md. Mahbubur
Description Background: Diffuse Large B-Cell Lymphoma (DLBCL), most common Non-Hodgkin Lymphoma (NHL) variety, is an aggressive, fast-growing form comprising up to 40% of all cases globally. Objective: To observe the treatment outcome of different subtypes of Diffuse Large B-Cell Lymphoma (DLBCL) after first-line chemotherapy and also the association with IHC, presenting age, sex, and IPI score with outcome. Methodology: This is a retrospective data analysis included all DLBCL patients registered in the department of Haematology of National Institute of Cancer Research and Hospital (NICRH) between July 2016 to June 2019. Results: Total 188 cases were included in this study and mean age was 48 years with a Standard deviation of 15 years with Male (69.1%) predominance. We divide the cases into three different entities of DLBCL [Germinal Centre B-cell like (GCB), Non-GCB and others (NOS) among them Non-GCB variety was the prevalent (47.3%) one. After first line   chemotherapy 52.1% complete remission with 7% death was observed in overall outcome. There was no significant difference in outcome among different types of DLBCL after chemotherapy based on Han’s algorithm. Rituximab with CHOP has significantly better outcome than CHOP alone arm (p: 0.021). Conclusion: This limited database study of NICRH will help to ascertain the outcome of DLBCL after first-line chemotherapy in Bangladesh.
Publisher Haematology Society of Bangladesh
Date 2021-06-09
Type info:eu-repo/semantics/article
Peer-Reviewed Article
Format text/html
Identifier https://journal.hematologybd.org/index.php/haematoljbd/article/view/56
Source Haematology Journal of Bangladesh; Vol. 5 No. 01 (2021); 03-09
Language eng
Relation https://journal.hematologybd.org/index.php/haematoljbd/article/view/56/202
Rights Copyright (c) 2020 Zulfia Zinat Chowdhury, Tamanna Bahar, Shaila Rahman, Salina Haque, A K M Mynul Islam, Mohammad Ali, Md. Mahbubur Rahman

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