Rethrombosis in COVID-19 patient

International Journal of Progressive Sciences and Technologies

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Title Rethrombosis in COVID-19 patient
Creator Kiliptari, Guliko

Description SARS-CoV-2 infection is associated with arterial and venous thrombotic complications. Autopsy findings revealed   microthrombi in multiple organ systems, that may contribute to multisystem organ dysfunction in severe COVID-19.Thrombosis in patients with COVID-19 is due to a cytokine storm, hypoxic injury, endothelial dysfunction and  increased platelet activity. Many difficult mechanisms contributes  formation clots in   vasculature of  multi organs ,  We presented two different cases of pulmonary artery thrombosis complicated by severe ARDS and rethrombosis in the branches of the pulmonary artery.Both  patient  was  treated  according  PE(pulmonary  embolism)  management  protocol (ESC)Conclusion: The  multisystem  mechanisms : The complement system , part of the innate immune response , capable of activating the coagulation cascade,  endothelial inflammation, loss of ACE2 and  alteration  of  PAI/tPA balance ,cytokine storm, high levels of the blood clotting protein factor, decreased concentrations of endogenous anticoagulant proteins   increasis  probability  of  new  thrombosis ,  despite  suitable treatment and  prevention
Publisher International Journals of Sciences and High Technologies
Date 2021-05-09
Type info:eu-repo/semantics/article
Peer-reviewed Article
Format application/pdf
Source International Journal of Progressive Sciences and Technologies; Vol 26, No 1 (2021); 464-471
Language eng
Rights Copyright (c) 2021 Guliko Kiliptari

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