Development and validation of analytical methods for the simultaneous estimation of Nimorazole and Ofloxacin in tablet dosage form

International Journal of Drug Delivery

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Field Value
 
Title Development and validation of analytical methods for the simultaneous estimation of Nimorazole and Ofloxacin in tablet dosage form
 
Creator Ghugare, A P; Department of Quality Assurance, Sharad Pawar College of Pharmacy, Wanadongri, Nagpur, Maharashtra, India.
Devhare, Lalchand Dayanand; Department of Quality Assurance, Sharad Pawar College of Pharmacy, Wanadongri, Nagpur, Maharashtra, India.
Hatwar, B P; Department of Quality Assurance, Sharad Pawar College of Pharmacy, Wanadongri, Nagpur, Maharashtra, India.
 
Subject Pharmaceutical Sciences
Ofloxacin, Nimorazole, Simultaneous equation method, Absorbance ratio method
 
Description Two simple, rapid, accurate and precise spectrophotometric methods have been developed for simultaneous estimation of Nimorazole and Ofloxacin from tablet dosage form. Method І involves formation of ‘simultaneous equations’ at 304 nm (λ max of Nimorazole) and 287.5 nm (λ max of Ofloxacin); while Method ІІ involves, formation of ‘Absorbance ratio equation’ at 301(isoabsorptive point) and 287.5 nm (λ max of Ofloxacin) using distilled water as a solvent. The linearity was observed in the concentration range of 5 - 25 μg/ml for Nimorazole and 2 - 10 μg/ml for Ofloxacin. The results of analysis have been validated statistically and by recovery studies and were found satisfactory.
 
Publisher Advanced Research Journals
 
Contributor
 
Date 2016-12-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/1792
10.5138/09750215.1792
 
Source International Journal of Drug Delivery; Vol 8, No 3 (2016): International Journal of Drug Delivery; 96-98
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/1792/pdf
 
Rights Copyright (c) 2016 Lalchand Dayanand Devhare
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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