Niosomal 5-Flourouracil gel for effective treatment of skin cancer; In-vitro and In-vivo evaluation

International Journal of Drug Delivery

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Field Value
 
Title Niosomal 5-Flourouracil gel for effective treatment of skin cancer; In-vitro and In-vivo evaluation
 
Creator Abdelbary, Ahmed; Department of Pharmaceutics, Faculty of Pharmacy Cairo University, Egypt
Salem, Heba F; Department of Pharmaceutics, Faculty of Pharmacy, Beni Suef University, Egypt
Khallaf, Rasha AbdelSalam; Department of Pharmaceutics, Faculty of Pharmacy, Beni Suef University, Egypt
 
Subject

 
Description This study was designated to form core-enriched 5-flourouracil (5-FU) niosomes and apply it to skin as a niosomal gel for topical treatment of skin cancer. Different molar ratios of the two surfactants used namely; sorbitan monostearate (Span 60), sorbitan monolaurate (Span 20) to cholesterol were employed, in addition; sodium deoxycholate was used a co-surfactant. The drug was successfully entrapped in niosomes with entrapment efficiency reached up to 67.08 ± 2.53 mg % (w/w). The produced niosomes had particle size below 300 nm, zeta potential values between -15 ± -1.6 and -37.73 ± -2.53 mV and polydispersity index between 0.09 ± 0.06 and 0.20 ± 0.02. Transmission electron microscopy showed the formation of spherical niosomes with closed bilayer structure. Formula N8 had more than two fold increase in amount permeated compared to free drug in in-vitro permeation study. The niosomal gel formulae had better permeation parameters compared to formulae containing free drug. Niosomal gel formula composed of sodium carboxymethyle cellulose (Na CMC) had the best permeation parameters among the produced gel formulae. Histopathological studies showed that niosomal 5-FU gel was able to penetrate more readily into deep layers of skin to treat tumor as indicated by the reduction in inflammatory reaction and hemorrhage signs observed in animals treated by niosomal 5-FU gel. 
 
Publisher Advanced Research Journals
 
Contributor
 
Date 2016-02-25
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/1800
 
Source International Journal of Drug Delivery; Vol 7, No 4 (2015): International Journal of Drug Delivery; 223-232
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/1800/pdf
 
Rights Copyright (c) 2015 Rasha Abdel Salam khallaf
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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