Preparation, optimization and in vivo evaluation of Eletriptan HBR fast dissolving oral films

International Journal of Drug Delivery

View Publication Info
Field Value
Title Preparation, optimization and in vivo evaluation of Eletriptan HBR fast dissolving oral films
Creator Kothapuvari, Pavan Kumar; Pacific University, Debari, Udaipur, Rajasthan-313024.
Rawat, Swati; S. N. D. College of Pharmacy, Babhulgaon, Nashik - 423401, Maharashtra.
Bhikshapathi, DVRN; Vijaya College of Pharmacy, Hayath Nagar, Hyderabad-501511, Telangana, India.
Subject Pharmaceutics; Drug Delivery
Eletriptan HBr, Migraine, Fast dissolving oral films, disintegration time, HPMC, Pharmacokinetics.
Description The present investigation was aimed with the objective of developing fast dissolving oral films of Eletriptan HBr in order to attain quick onset of action for the better management of migraine attack. Twenty five formulations were prepared by solvent casting method using different polymer types, plasticizer types, surfactant concentrations and different ratio of hydroxypropyl methyl cellulose and maltodextrin. The prepared films were evaluated for folding endurance, thickness, drug content, in vitro/in vivo disintegration time, drug release and tensile test. The optimized formulation F17 containing HPMC 15cp and maltodextrin showed minimum in vitro disintegration time 11 seconds, highest dissolution rate i.e. 98.5% of drug within 10 min. The optimized film was further evaluated for bioavailability compared with a marketed product (Relpax-20mg). The pharmacokinetic results revealed that the fast dissolving oral films has higher peak blood concentration (Cmax, 0.455±0.1µg/ml) within shorter time (Tmax, 0.5 hours), indicating rapid absorption and faster onset of action with acceptable bioavailability value. Therefore, the oral fast dissolving film is considered to be potentially useful for the treatment of migraine disease where quick onset of action is desired, also improved patient compliance.
Publisher Advanced Research Journals
Date 2015-12-28
Type info:eu-repo/semantics/article

Format application/pdf
Source International Journal of Drug Delivery; Vol 7, No 3 (2015): International Journal of Drug Delivery; 141-154
Language eng
Rights Copyright (c) 2015 Pavan Kumar Kothapuvari, Swati Rawat, DVRN Bhikshapathi

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us


Copyright © 2015-2018 Simon Fraser University Library