Limonene and BEZ 235 inhibits growth of COLO-320 and HCT-116 colon cancer cells

International Journal of Drug Delivery

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Field Value
 
Title Limonene and BEZ 235 inhibits growth of COLO-320 and HCT-116 colon cancer cells
 
Creator yakkanti, Raja Ratna Reddy; Sugen Life Sciences Pvt Ltd., Tirupati, A P, India.
Sekhar, P Chandra; Manipal University, Manipal, Karnataka, India. and Palamur Biosciences Pvt Ltd., Mahabubnagar, Telangana, India.
Reddy, K Bharath Nandhan; S.V.S Medical College, Mahabubnagar, Telangana, India
Ramamoorthy, S; Palamur Biosciences Pvt Ltd., Mahabubnagar, Telangana, India.
Suresh, S Ranga; Palamur Biosciences Pvt Ltd., Mahabubnagar, Telangana, India.
Lakshmi, T Yasodha; Palamur Biosciences Pvt Ltd., Mahabubnagar, Telangana, India.
Rajesh, Mani; Palamur Biosciences Pvt Ltd., Mahabubnagar, Telangana, India.
Reddy, C Damodar; Sugen Life Sciences Pvt Ltd., Tirupati, A P, India.
 
Subject cancer biology; drug development; phytotherapy
Colorectal cancer, limonene, BEZ235, Ras, PI3K
 
Description D-Limonene is a dietary monoterpene with significant anticancer activity against many cancer types in preclinical and clinical studies. The study is designed to investigate synergistic anticancer effects of limonene and BEZ235 combination in COLO-320 and HCT-116 colon cancer cells. Cells were treated with both the drugs alone and in combination and the effects on cell viability; cell migration and clonogenic potential were examined. Results show that both drugs exhibited dose and time dependant cytotoxicity on the cell lines tested. CompuSyn analysis of the drug combination effects revealed the strong synergistic interaction of the combination. Our results also indicate that COLO-320 cells were more sensitive for anticancer effects of the drugs than HCT-116 cells. The presence of Ras and PI3K mutations in HCT-116 cells could possibly be one of the main reasons for the observed outcome as compared to the wild type expressions of them in COLO-320 cells.
 
Publisher Advanced Research Journals
 
Contributor Sugen Life Sciences
Manipal University
SVS Medical COllege
Palamur Biosciences
 
Date 2016-12-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/1919
10.5138/09750215.1919
 
Source International Journal of Drug Delivery; Vol 8, No 3 (2016): International Journal of Drug Delivery; 89-95
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/1919/pdf
 
Rights Copyright (c) 2016 raja ratna reddy yakkanti
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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