Two-Photon-Absorption Triggered Release of 5-Fluorouracil from Isomer-Pure Polymer Bound Syn-Head-to-Head Dimers for Novel Intraocular Lenses

International Journal of Drug Delivery

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Field Value
 
Title Two-Photon-Absorption Triggered Release of 5-Fluorouracil from Isomer-Pure Polymer Bound Syn-Head-to-Head Dimers for Novel Intraocular Lenses
 
Creator Busch, Annegret P.; University of Marburg, Department of Chemistry, Hans-Meerwein-St. 4 35032 Marburg, Germany
Hampp, Norbert A.; University of Marburg Department of Chemistry Hans-Meerwein-Str. 4 35032 marburg
 
Subject Drug Delivery
Photo-triggered drug release, 5-fluorouracil, isomers, two-photon-absorption, [2+2] cycloreversion, acrylic polymer
 
Description Different stereoisomers of the cytotoxic 5-fluorouracil (5FU) homodimers were synthesized by photochemical [2+2]-cycloaddition and polymerized into MMA/HEMA to form a novel drug-loaded copolymer for intraocular lenses as irradiation-activated treatment for secondary cataract. Three isomers were obtained, and showed significant differences in cleavage efficiency on photo-cleavage via single-photon-absorption (SPA) and two-photon-absorption (TPA). The most efficient TPA cleavage rate was observed for the syn-head-to-head 5FU dimer, which was, consequently, used for drug loading of the polymeric material to obtain a drug-loaded material of higher efficiency compared to previous works. The light and thermal stability of the polymer were confirmed and multi-dose release of the drug in aqueous solution for possible repeated treatment of cataract was proven.
 
Publisher Advanced Research Journals
 
Contributor Prof. Dr. Marcus Motzkus
Dr. Tiago Buckup, both University of Heidelberg
Financial support by the German Ministry of Education and Research (BMBF) through grant FKZ 13N10946
 
Date 2015-12-28
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/1725
 
Source International Journal of Drug Delivery; Vol 7, No 3 (2015): International Journal of Drug Delivery; 174-190
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/1725/pdf
http://www.arjournals.org/index.php/ijdd/article/downloadSuppFile/1725/650
 
Rights Copyright (c) 2015 Norbert A. Hampp
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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