Effect of Unsaturated Fatty Acid Omega-3 on Some Biochemical Criteria in White New Zealand Rabbits Administrated with Cyclosporine Drug

Medical Science Journal for Advance Research (MSJAR)

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Field Value
 
Title Effect of Unsaturated Fatty Acid Omega-3 on Some Biochemical Criteria in White New Zealand Rabbits Administrated with Cyclosporine Drug
 
Creator Jawad, Murtadha M.
 
Subject Cyclosporine
omega-3
High density lipoprotein
Low density lipoprotein
 
Description The present study was aimed efficiency to evaluate the unsaturated fatty acid omega-3 in reducing the side effects that resulted from the administration of cyclosporine drug in white rabbits. (60) white males' rabbits were used in this study, divided into four groups contain (15) rabbits per group and its subdivision into three groups (5) rabbits per group. The first group is orally administered with normal saline, the second group was administered cyclosporine (25mg/kg) only. Third groups were administered cyclosporine on the first day and omega-3 (500mg/kg) on the second day, while Fourth groups were administered cyclosporine on the first day and omega-3 (1000mg/kg) on the second day for periods (21,30,60) days respectively. After ending study periods, the animals were sacrificed and the blood was collected and the results were shown the following:  Administration with cyclosporine (25mg/kg)only and for periods were led to a significant increase(P<0.05) in total cholesterol, triglycerides and low-density lipoprotein(LDL) and a significant decrease(P<0.05) in high-density lipoprotein(HDL).whereas interaction with (500&1000mg/kg) of omega-3 and to all periods showed a significant decrease (p<0.05) in the total cholesterol, triglycerides and low-density lipoprotein(LDL) and significant decrease(p<0.05) in high-density lipoprotein(HDL), while the non-significant difference in high-density lipoprotein(HDL). This study concluded that omega-3 has an important role in reducing biochemistry side effects that result from the administration of cyclosporine drugs in white rabbits.
 
Publisher Research and Education Development (READ) Institute
 
Date 2021-03-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://medical.science.journal-asia.education/index.php/msjar/article/view/14
10.46966/msjar.v2i1.14
 
Source Medical Science Journal for Advance Research; Vol. 2 No. 1 (2021): March 2021 - Medical Science Journal for Advance Research; 15-24
2774-4892
2776-3870
10.46966/msjar.v2i1
 
Language eng
 
Relation https://medical.science.journal-asia.education/index.php/msjar/article/view/14/10
 
Rights Copyright (c) 2021 Murtadha M. Jawad
https://creativecommons.org/licenses/by/4.0
 

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