Microbiota and age-related macular degeneration: where are we today?


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Field Value
Title Microbiota and age-related macular degeneration: where are we today?
Creator Minnella, Angelo Maria
Albanesi, Francesca
Maceroni, Martina
Subject Age-related macular degeneration
Gut-retina axis
Leaky gut
Personalized medicine
Description Age-related macular degeneration (AMD) is a complex degenerative multifactorial retinal disease, representing a leading cause of legal blindness among elderly individuals. It is well known that age, family history, smoking, nutrition, and inflammation contribute to the development of AMD. Recent studies support the existence of a gut-retina axis involved in the pathogenesis of several ocular diseases, including AMD. High-fat and high simple sugar diets determine a derangement of the gut microbiota, with an increase of gut permeability and systemic low-grade inflammation. Leaky gut is correlated with higher levels of circulating microbial-associated pattern molecules, which trigger the systemic release of potent proinflammatory mediators and stimulate the specific immune cells of the retina, contributing to retinal damage. All these findings suggest that microbiota is closely related to AMD and that it may be targeted in order to influence AMD pathogenesis and/or its clinical course.
Publisher AboutScience srl - Piazza Duca d'Aosta 12 - 20124 Milano MI (Italy)
Date 2021-04-07
Type info:eu-repo/semantics/article
Review article
Format application/pdf
Identifier https://journals.aboutscience.eu/index.php/aboutopen/article/view/2241
Source AboutOpen; Vol. 8 No. 1 (2021): January-December 2021; 23-28
AboutOpen; V. 8 N. 1 (2021): January-December 2021; 23-28
Language eng
Relation https://journals.aboutscience.eu/index.php/aboutopen/article/view/2241/2317
Rights Copyright (c) 2021 The authors

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