Microbiota and age-related macular degeneration: where are we today?
AboutOpen
View Publication Info| Field | Value | |
| Title |
Microbiota and age-related macular degeneration: where are we today?
|
|
| Creator |
Minnella, Angelo Maria
Albanesi, Francesca Maceroni, Martina |
|
| Subject |
Age-related macular degeneration
Gut-retina axis Leaky gut Microbiota Micronutrients Personalized medicine |
|
| Description |
Age-related macular degeneration (AMD) is a complex degenerative multifactorial retinal disease, representing a leading cause of legal blindness among elderly individuals. It is well known that age, family history, smoking, nutrition, and inflammation contribute to the development of AMD. Recent studies support the existence of a gut-retina axis involved in the pathogenesis of several ocular diseases, including AMD. High-fat and high simple sugar diets determine a derangement of the gut microbiota, with an increase of gut permeability and systemic low-grade inflammation. Leaky gut is correlated with higher levels of circulating microbial-associated pattern molecules, which trigger the systemic release of potent proinflammatory mediators and stimulate the specific immune cells of the retina, contributing to retinal damage. All these findings suggest that microbiota is closely related to AMD and that it may be targeted in order to influence AMD pathogenesis and/or its clinical course.
|
|
| Publisher |
AboutScience srl - Piazza Duca d'Aosta 12 - 20124 Milano MI (Italy)
|
|
| Date |
2021-04-07
|
|
| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Review article |
|
| Format |
application/pdf
application/epub+zip text/html |
|
| Identifier |
https://journals.aboutscience.eu/index.php/aboutopen/article/view/2241
10.33393/ao.2021.2241 |
|
| Source |
AboutOpen; Vol. 8 No. 1 (2021): January-December 2021; 23-28
AboutOpen; V. 8 N. 1 (2021): January-December 2021; 23-28 2465-2628 |
|
| Language |
eng
|
|
| Relation |
https://journals.aboutscience.eu/index.php/aboutopen/article/view/2241/2317
https://journals.aboutscience.eu/index.php/aboutopen/article/view/2241/2318 https://journals.aboutscience.eu/index.php/aboutopen/article/view/2241/2319 |
|
| Rights |
Copyright (c) 2021 The authors
|
|
