Microbiota and age-related macular degeneration: where are we today?

AboutOpen

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Field Value
 
Title Microbiota and age-related macular degeneration: where are we today?
 
Creator Minnella, Angelo Maria
Albanesi, Francesca
Maceroni, Martina
 
Subject Age-related macular degeneration
Gut-retina axis
Leaky gut
Microbiota
Micronutrients
Personalized medicine
 
Description Age-related macular degeneration (AMD) is a complex degenerative multifactorial retinal disease, representing a leading cause of legal blindness among elderly individuals. It is well known that age, family history, smoking, nutrition, and inflammation contribute to the development of AMD. Recent studies support the existence of a gut-retina axis involved in the pathogenesis of several ocular diseases, including AMD. High-fat and high simple sugar diets determine a derangement of the gut microbiota, with an increase of gut permeability and systemic low-grade inflammation. Leaky gut is correlated with higher levels of circulating microbial-associated pattern molecules, which trigger the systemic release of potent proinflammatory mediators and stimulate the specific immune cells of the retina, contributing to retinal damage. All these findings suggest that microbiota is closely related to AMD and that it may be targeted in order to influence AMD pathogenesis and/or its clinical course.
 
Publisher AboutScience srl - Piazza Duca d'Aosta 12 - 20124 Milano MI (Italy)
 
Date 2021-04-07
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Review article
 
Format application/pdf
application/epub+zip
text/html
 
Identifier https://journals.aboutscience.eu/index.php/aboutopen/article/view/2241
10.33393/ao.2021.2241
 
Source AboutOpen; Vol. 8 No. 1 (2021): January-December 2021; 23-28
AboutOpen; V. 8 N. 1 (2021): January-December 2021; 23-28
2465-2628
 
Language eng
 
Relation https://journals.aboutscience.eu/index.php/aboutopen/article/view/2241/2317
https://journals.aboutscience.eu/index.php/aboutopen/article/view/2241/2318
https://journals.aboutscience.eu/index.php/aboutopen/article/view/2241/2319
 
Rights Copyright (c) 2021 The authors
 

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