Administration of ethanol extract of Bajakah tampala (Spatholobus littoralis Hassk) stem decreased reactive oxygen species, visceral fat and body weight of obese rats

Neurologico Spinale Medico Chirurgico

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Title Administration of ethanol extract of Bajakah tampala (Spatholobus littoralis Hassk) stem decreased reactive oxygen species, visceral fat and body weight of obese rats
 
Creator Novanty, Vany
Pangkahila, Wimpie
Dewi, Ni Nyoman Ayu
 
Subject Bajakah tampala
Reactive oxygen species
Visceral fat weight
Body weight
Obesity
 
Description Background: Oxidative stress plays a role in the obesity mechanism, thus leads to premature aging. High antioxidant capacity in Bajakah tampala stem may effectively lessen oxidative stress and reduce fat mass and body weight accordingly. This study aimed to provide Bajakah tampala stem extract's effect in lowering ROS level, visceral fat weight, and overall weight of obese male Wistar rats.
Method: A true experimental design was conducted on male Wistar rats aged 2-3 months with obesity. Thirty-two obese rats were evenly divided into a placebo group and a group given Bajakah tampala stem extract, with 16 rats in each group. For 28 days, both groups were fed a high-fat diet. The subject body weights were weighed every week. ROS levels and visceral fat weight were evaluated after the intervention was done. Comparative analysis between groups was performed.
Results: The results showed mean levels of ROS (56.2 ± 7.4 U/ml vs. 400.9 ± 50.7 U/ml; p < 0.001), visceral fat weight (2.6 ± 0.2 g vs. 3.4 ± 0.9 g; p < 0.001), and the final body weight (241.5 ± 2.8 g vs. 261.5 ± 13.8 g; p < 0.001) were significantly lower in the study group than the control group.
Conclusion: The study indicates Bajakah tampala stem extract administration effectively reduced ROS levels, visceral fat weight, and body weight in obese male Wistar rats.
 
Publisher Indoscholar
 
Date 2021-03-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://nsmc.indoscholar.com/index.php/nsmc/article/view/150
10.36444/nsmc.v4i1.150
 
Source Neurologico Spinale Medico Chirurgico; Vol 4 No 1 (2021); 32-36
2621-2064
 
Language eng
 
Relation https://nsmc.indoscholar.com/index.php/nsmc/article/view/150/117
 
Rights Copyright (c) 2021 Neurologico Spinale Medico Chirurgico
https://creativecommons.org/licenses/by/4.0
 

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