Terminalia ferdinandiana inhibited the increased of matrix metalloproteinase-1 and prevent collagen decreased in mice skin exposed to UV-B

Neurologico Spinale Medico Chirurgico

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Title Terminalia ferdinandiana inhibited the increased of matrix metalloproteinase-1 and prevent collagen decreased in mice skin exposed to UV-B
 
Creator Emy, Shalihaty
Iswari, Ida Sri
Winarti, Ni Wayan
 
Subject Collagen
MMP-1 expression
Kakadu plum extract
UV-B
 
Description Background: Kakadu cream contained 0,1% Kakadu plum (Terminalia ferdinandiana) extract with a high content of phenolic compound, flavonol, tocopherol, luthein, chlorophyll, and ellagic acid has potential to prevent the Ultraviolet-B (UV-B) effect on skin aging acceleration. To date, there’s no in vivo experiment on the effect of kakadu plum extract on collagen nor matrix metalloproteinase-1 (MMP-1). This research aims to evaluate the effectiveness of Kakadu cream administration in inhibiting the increase of MMP-1 expressions and prevent the decrease of collagen amount in mice (Mus musculus) skin exposed to UV-B.
Methods: An experimental study with a post-test only control group design was employed in 36-male-mice, 6-8 weeks old, weighing 20-25 grams. The samples were divided randomly into two groups, a control group given base cream and the study group, given Kakadu cream 0,1% on their shaved backs, 1 cm2 in size as the UV-B exposure's location. The UV-B irradiation was done three times a week for 4-weeks. The base and Kakadu cream were given twice a day. Comparative analysis was carried out to compare MMP-1 expression and collagen amount in both groups.
Results: The results show that the mean of MMP-1 expression on the study group was significantly lower compared to control group (p<0.001). The mean collagen amount was significantly higher in the study group than in the control group (p< 0,001).
Conclusion: From the results, can be concluded that Kakadu cream inhibited the increase MMP-1 expression and prevent the decrease of collagen amount in mice skin exposed to UV-B.
 
Publisher Indoscholar
 
Date 2021-03-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://nsmc.indoscholar.com/index.php/nsmc/article/view/136
10.36444/nsmc.v4i1.136
 
Source Neurologico Spinale Medico Chirurgico; Vol 4 No 1 (2021); 11-14
2621-2064
 
Language eng
 
Relation https://nsmc.indoscholar.com/index.php/nsmc/article/view/136/111
 
Rights Copyright (c) 2021 Neurologico Spinale Medico Chirurgico
https://creativecommons.org/licenses/by/4.0
 

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