Ocorrência de zumbido e neuropatia sensorial periférica em mulheres durante tratamento quimioterápico de câncer de mama

Revista Ciências em Saúde

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Title Ocorrência de zumbido e neuropatia sensorial periférica em mulheres durante tratamento quimioterápico de câncer de mama
Occurrence of tinnitus and peripheral sensory neuropathy in women during chemotherapy treatment of breast cancer
 
Creator Kameo, Simone Yuriko
Barbosa-Lima, Ricardo
Duarte, Josilene Luciene
Amorim, Bruno Ferreira
Silva, Glebson Moura
Marinho, Pabliane Matias Lordelo
Sawada, Namie Okino
 
Subject breast neoplasms
drug-related side effects and adverse reactions
drug therapy
ototoxicity
tinnitus
neoplasias da mama
efeitos colaterais e reações adversas relacionados a medicamentos
tratamento farmacológico
ototoxicidade
zumbido
 
Description Objetivo: Analisar a ocorrência de zumbido e neuropatia sensorial periférica em mulheres durante quimioterapia para câncer de mama. Métodos: Trata-se de um estudo analítico e retrospectivo com abordagem quantitativa, realizado em prontuários de um serviço ambulatorial de oncologia entre fevereiro de 2014 e fevereiro de 2015, utilizando os escores de toxicidades do Common Terminology Criteria for Adverse Events (CTCAE). Resultados: Das 181 pacientes com câncer de mama que atenderam aos critérios de inclusão, 49.2% relataram zumbido e 65.1% neuropatia sensorial periférica em algum momento do tratamento. Em ambas as condições, o escore de gravidade predominante foi grau 1, com frequências de 23.8% e 33.1%, respectivamente. Foi observada uma correlação significativa, positiva e fraca entre a severidade do zumbido e da neuropatia sensorial periférica (ρ = 0,325 e p = 0,001), bem como muito fraca entre a quantidade de ciclos completos de quimioterapia e zumbido (ρ = 0,195 e p = 0,009) e neuropatia sensorial periférica (ρ = 0,237 e p = 0,002). Conclusões: Zumbido e neuropatia sensorial periférica foram toxicidades frequentes durante o tratamento quimioterápico do câncer de mama e ambos se manifestaram com baixa gravidade/impacto funcional na maioria das participantes.
Objective: To analyze the occurrence of tinnitus and peripheral sensory neuropathy in women during breast cancer chemotherapy. Methods: This is a retrospective analytical study with a quantitative approach, performed in medical records of an oncology outpatient service between February 2014 and February 2015, using the toxicities scores of Common Terminology Criteria for Adverse Events (CTCAE). Results: Considering 181 patients with breast cancer who met the inclusion criteria, 49.2% reported tinnitus at some point of the treatment, while 65.1% peripheral sensory neuropathy. In both conditions, the predominant severity score was grade 1, with frequencies of 23.8% and 33.1%, respectively. A significant, positive and weak correlation was observed between the severity of tinnitus and peripheral sensory neuropathy (ρ = 0.325 and p = 0.001), as well as very weak between the number of complete cycles of chemotherapy and tinnitus (ρ = 0.195 and p = 0.009) and neuropathy peripheral sensory (ρ = 0.237 and p = 0.002). Conclusions: Tinnitus and peripheral sensory neuropathy were frequent toxicities during chemotherapy treatment of breast cancer, and both manifested with low severity/functional impact in most participants.
 
Publisher AISI/HCI
 
Date 2021-03-16
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer reviewed
text
Avaliado pelos pares
texto
 
Format application/pdf
text/xml
text/html
 
Identifier http://186.225.220.186/ojs/index.php/rcsfmit_zero/article/view/1089
10.21876/rcshci.v11i1.1089
 
Source Health Sciences Journal; Vol 11 No 1 (2021): January to March 2021; 69-79
Revista Ciências em Saúde; v. 11 n. 1 (2021): Janeiro a Março de 2021; 69-79
2236-3785
10.21876/rcshci.v11i1
 
Language eng
 
Relation http://186.225.220.186/ojs/index.php/rcsfmit_zero/article/view/1089/679
http://186.225.220.186/ojs/index.php/rcsfmit_zero/article/view/1089/694
http://186.225.220.186/ojs/index.php/rcsfmit_zero/article/view/1089/695
 
Rights Copyright (c) 2021 Health Sciences Journal
https://creativecommons.org/licenses/by-nc-sa/4.0
 

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