Mitochondrial Metabolism, Dysfunctions in Senescence Cell and the Possible Interventions through Herbal Medicines

International Journal of Aging Research

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Field Value
 
Title Mitochondrial Metabolism, Dysfunctions in Senescence Cell and the Possible Interventions through Herbal Medicines
 
Creator Ferro M.*, Graubard A., Escalante P., Ledezma R., Channan G., Mia N., Dotres V., Bencomo Y., Datri P.
 
Subject Mitochondrial Biogenesis; Cell Senescence; Retrograde Signaling; Medicinal Herbs
 
Description The mitochondria are the cell`s powerhouse. They are considered ubiquitous organelles of all eukaryotic cells, being responsible for the cell’s life and death cycle. Through stimuli in the environment in which they live, mitochondria can modulate their own biogenesis as well as signal retrograde to the nucleus to modify the structure of their proteins. Since the mitochondrial genome contains only 37 genes, much of the encoding of its proteins depends on the nuclear genome. Thus, the communication between mitochondria and the nucleus seems to be a target of science in understanding the pathologies associated with this organelle. Some medicinal herbs have been shown to influence mitochondrial biogenesis, such as Gynostemma pentaphyllun (GP) and berberine, which increase the phosphorylation of proteins AMPactivated protein kinase (AMPK). Just as GP and berberine phosphorylate AMPK in signaling for mitochondrial biogenesis, the sesquiterpene beta-caryophyllene (BCP) demonstrated positive results in reorganizing mitochondrial transcription factors, being an agonist of the peroxisome proliferatoractivated alpha receptor (PPAR-?). Another plant derivative, the non-psychoactive cannabinoid known as cannabidiol (CBD), has been showing control in the metabolism of calcium in the mitochondrial matrix. In this review, we seek to get a closer look at the biochemical mechanisms of action of some of these plants, as well as their synergies in the results of different treatments. In the view of oriental medicines, the use of associated medicinal herbs has always been part of their treatment protocols. However, the effectiveness of these treatments in relation to plant synergy can be observed in future clinical trials for better understanding.
 
Publisher eSciPub LLC
 
Date 2021-03-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://escipub.org/index.php/IJOAR/article/view/389
10.28933/ijoar-2021-02-1206
 
Source International Journal of Aging Research; Vol. 4 No. 1 (2021): International Journal of Aging Research; 78
2637-3742
 
Language eng
 
Relation https://escipub.org/index.php/IJOAR/article/view/389/374
 
Rights https://creativecommons.org/licenses/by-nc/4.0/
 

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