The Effect of Ferric Carboxymaltose Versus Iron Sucrose on Hemoglobin Levels in Pregnant Women with Anemia: Meta-Analysis

Journal of Maternal and Child Health

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Title The Effect of Ferric Carboxymaltose Versus Iron Sucrose on Hemoglobin Levels in Pregnant Women with Anemia: Meta-Analysis
Creator Nirwana, Astika Candra
Dewi, Yulia Lanti Retno
Murti, Bhisma
Description Background:  Anemia in pregnant women is one of the global health problems experienced by deve­­­loped or developing countries affecting 1.62 billion world population, which corresponds to 24.8% of the population in the world. Anemia is a serious problem for mater­nal health because it is one of the five problems that becomes the target of solving the World Health Organization (WHO) in 2025. This study aimed to estimate the mag­nitude of the effect of Ferric Carboxymaltose on hemoglobin levels in pregnant women with anemia compared to Iron Sucrose.Subjects and Method: This study was a meta-analysis study. The study was conducted by look­ing for data from the study results in the period 2010-2019. The data of this study was from Pubmed, DOAJ, Science Direct, Springer Link, Web of Science, Cochrane, Google Scholar, BMJ, BMC, Research Gate, J Stor, Wiley, Clinical Key, J Gate, SAGE, IEEE Xplore, ERIC Institute of Education Science, BASE, SciELO, WorldCat, Microsoft Academic, Index Copernicus, CABI, Cambridge, Nature, Oxford, ProQuest, and BJOG using the keyword "ferric carboxymaltose" AND "iron sucrose" AND "anemia in pregnancy" AND "ran­do­mized control trial" OR RCT, "ferric carboxy­maltose" AND "iron sucrose" AND "hemo­globin in pregnancy" AND "randomized control trial".  The subjects of this study were pregnant women with anemia. The study used a Revman 5.3 application to analyze the article.Results: The eight articles were reviewed using the meta-analysis technique in this study. Preg­nant women who were given ferric carboxy­maltose therapy had a higher mean hemoglobin level than those who were not treated carboxy­maltose therapy and it was  statistically signi­fi­cant (SMD= 1.11; 95% CI= 0.37 to 1.85; p= 0.003). The heterogeneity of the data showed I2= 98% so that the distribution of the data was stated to be heterogeneous (random effect model).Conclusion: Ferric Carboxymaltose is effec­tive in increasing hemoglobin levels in preg­nant women with anemia.Keywords: Ferric Carboxymaltose, Iron Sucrose, Randomized Controlled Trial.Correspondence: Astika Candra Nirwana. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: astikacandranirwana2796@­g­ Mobile: 085640018896.Journal of Maternal and Child Health (2021), 06(01): 15-24 
Publisher Journal of Maternal and Child Health
Date 2021-03-06
Type info:eu-repo/semantics/article
Peer-reviewed Article
Format application/pdf
Source Journal of Maternal and Child Health; Vol 6, No 1 (2021); 15-24
Language eng
Rights Copyright (c) 2021 Journal of Maternal and Child Health

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