Elevated Serum Reactive Oxygen Species Level Predicts Early Abortion

Molecular and Cellular Biomedical Sciences

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Title Elevated Serum Reactive Oxygen Species Level Predicts Early Abortion
Creator Serudji, Joserizal
Irawati, Nuzulia
Mose, Johanes Cornelius
Ali, Hirowati
Yusrawati, Yusrawati
Description Background: Impaired trophoblast invasion is associated with early abortion. The calorie needed for the trophoblast cell (TC) invasion is mainly met by adenosine triphosphate (ATP) produced in the mitochondria. Reactive oxygen species (ROS), byproduct of ATP synthesis, plays an important role in cellular physiology, but a high level of ROS may result in deoxyribonucleic acid (DNA) damage or cell dysfunction, thereby impaired TC invasion leading to early abortion. The study aims to determine elevated serum ROS level to predicts early abortion.Materials and method: This was an observational study with a cross-sectional design. Fifty subjects with gestational age less than 12 weeks, consist of 25 early abortions and 25 normal pregnancies subjects, were included in this study. Clinical examination and diagnosis are carried out in 2 Hospitals and 5 Public Health Centers in Padang. Examination of ROS levels was carried out by enzyme-linked immunosorbent assay (ELISA) in the Biomedical Laboratory, Faculty of Medicine, Universitas Andalas. The Mann-Whitney test was used to analyze the difference of serum ROS levels, with a significance level of 0.05.Results: The subjects of the two study groups were equivalent in terms of age, gestational age, and gravidity (p=0.051, p=0.453, and p=1.000). The median ROS levels were found to be 1.36 (1.02-26.30) ng/mL in the early abortion and 1.20 (0.43-2.75) ng/mL in the normal pregnancy (p=0.003).Conclusion: There is a significant difference between ROS levels in early abortion and normal pregnancy.Keywords: ROS, early abortion, normal pregnancy
Publisher Cell and BioPharmaceutical Institute
Contributor Andalas University
Date 2021-03-01
Type info:eu-repo/semantics/article

Format application/pdf
Identifier https://cellbiopharm.com/ojs/index.php/MCBS/article/view/192
Source Molecular and Cellular Biomedical Sciences; Vol 5, No 1 (2021); 37-40
Language eng
Relation https://cellbiopharm.com/ojs/index.php/MCBS/article/view/192/72
Rights Copyright (c) 2021 Joserizal Serudji, Nuzulia Irawati, Johanes C Mose, Hirowati Ali, Yusrawati Yusrawati

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