Autologous Stem Cell Transplantation in Multiple Myeloma Patients Over 60 Years Old

Medical Laboratory Technology Journal

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Title Autologous Stem Cell Transplantation in Multiple Myeloma Patients Over 60 Years Old
Creator Uncu Ulu, Bahar
Yiğenoğlu, Tuğçe Nur
Başcı, Semih
Bakırtaş, Mehmet
Şahin, Derya
Darçın, Tahir
Yıldız, Jale
Merdin, Alparslan
Baysal, Nuran Ahu
İskender, Dicle
Dal, Mehmet Sinan
Kızıl Çakar, Merih
Altuntaş, Fevzi
Autologous stem cell transplantation; elderly; multiple myeloma; upfront; 60 years old
Description The incidence of Multiple myeloma (MM) increases with age; two-thirds of the patients are older than 65 years. Induction treatment, including new agents such as thalidomide, bortezomib, and lenalidomide followed by a conditioning regimen and upfront autologous stem cell transplantation (ASCT), has been accepted the standard treatment approach for newly diagnosed fit MM patients. We aimed to search the real-life data, the efficacy and safety of upfront ASCT following induction in patients with MM over 60 years old retrospectively. The data of MM patients who were ≥60 years old during autologous stem cell transplantation and treated at our center between 2010 and 2018 retrospectively analyzed. The study results were 63 patients included at the age of ≥ 60 years who underwent upfront ASCT. Median PFS was 15.5±2.6 months, and the median overall survival (OS) was 28.15±5 months. According to age groups, median PFS was 12±2.3 months in the 60-64 age group, 18.4±6 months in the 65-69 age group, and 26±15 months in the ≥70 age group. Median OS was 26.5±6.1 months in the 60-64 age group, 39.66±8.9 months in the 65-69 age group, and 18 months in the ≥70 age group. A significant relationship between the quantity of infused CD34+ stem cells and PFS and OS (p:0.05 and p
Publisher Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan
Contributor none
Date 2021-06-18
Type info:eu-repo/semantics/article
Peer-reviewed Article
Format application/pdf
Source Medical Laboratory Technology Journal; Vol 7, No 1 (2021): June; 18-25
Language eng
Rights Copyright (c) 2021 Semih Başcı

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