Relation Hepcidin with Renal Failure

Medical Science Journal for Advance Research (MSJAR)

View Publication Info
 
 
Field Value
 
Title Relation Hepcidin with Renal Failure
 
Creator Ali, Dr. Rusul Arif Abd
 
Subject Renal Failure
glomerular filtration rate (GFR)
Hepcidin
 
Description Renal failure refers to a condition where the kidneys lose their normal functionality, which may be due to various factors including infections, auto immune diseases, diabetes and other endocrine disorders, cancer, and toxic chemicals. It is characterized by the reduction in the excretory and regulatory functions of kidney. Biochemically, it is typically detected by an elevated serum creatinine. In the science of physiology it is described as a decrease in glomerular filtration rate (GFR). Hepcidin is a peptide produced primarily in the liver. Its mature form consists of 25 amino acids with a calculated mass of 2.8 kDa . Hepcidin has a key role in iron homeostasis by interacting with ferroportin. Hepcidin is the regulator of iron homeostasis in humans and other mammals. In humans, HAMP is the gene that encodes for hepcidin. 25-amino acid peptide was first identified in human urine and plasma. This peptide contains four disulfide bonds. It is synthesized, processed and secreted primarily by hepatocytes. In vitro, human hepcidin has anti-bacterial and antifungal activities. The 25-amino acid peptide of hepcidin is secreted by the liver, which seems to be the "master regulator" of iron metabolism.
 
Publisher Research and Education Development (READ) Institute
 
Date 2020-12-04
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://medical.science.journal-asia.education/index.php/msjar/article/view/9
10.46966/msjar.v1i01.9
 
Source Medical Science Journal for Advance Research; Vol. 1 No. 01 (2020): December 2020 - Medical Science Journal for Advance Research; 12-17
2774-4892
2776-3870
10.46966/msjar.v1i01
 
Language eng
 
Relation https://medical.science.journal-asia.education/index.php/msjar/article/view/9/5
 
Rights Copyright (c) 2020 Dr. Rusul Arif Abd Ali
https://creativecommons.org/licenses/by/4.0
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library