Intra Vaginal Drug Delivery System (Novel Drug Delivery System)

International Journal for Research in Applied Sciences and Biotechnology

View Publication Info
 
 
Field Value
 
Title Intra Vaginal Drug Delivery System (Novel Drug Delivery System)
 
Creator Ankit Kumar
Sanjeev Kumar
 
Subject VDDS
LHRH
vaginal immunization
bioadhesion
HYAFF
 
Description In case of intra-vaginal route of drug administration the dosage form is applied vaginally for the convenient release of the dosage form and for better therapeutic action of the medicament, it is usually used in HIV patients. many conditions that affect the  female reproductive tract, such as , sexually transmitted diseases, fungal & bacterial infections,  cancer and various pathogens such as virus (human immunodeficiency virus, HIV), bacteria (Gardnerella vaginalis), fungi (Candida spp.) or parasites (Trichomonas vaginalis). Systemically active drugs (contraceptive steroids) as well as locally active drugs (metronidazole Zidovudine, Lamivudine) can be effectively delivered for an extended period of time by the help of intra-vaginal  controlled release system. Continuous infusion of drugs through vaginal mucosa results in the reduced possibilities of Hepatic- gastrointestinal first-pass metabolism, gastric impatience of drugs and vacillation of dosing interval. Current study focus on the, use of various polymers which are used in hydrogels, these polymers provide bioadhesive property to the vaginal formulations, so that the vaginal formulation remains on vaginal tissues for 3- 4 days. Currently available vaginal dosage forms have several limitations, such as leakage and messiness necessitating the need to develop novel drug delivery systems.
 
Publisher Vandana Publications
 
Date 2020-12-26
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://www.ijrasb.com/ojs/index.php/ojs-ijrasb/article/view/245
10.31033/ijrasb.7.6.33
 
Source International Journal for Research in Applied Sciences and Biotechnology; Vol. 7 No. 6 (2020): November Issue; 234-241
2349-8889
 
Language eng
 
Relation https://www.ijrasb.com/ojs/index.php/ojs-ijrasb/article/view/245/196
 
Rights Copyright (c) 2020 International Journal for Research in Applied Sciences and Biotechnology
https://creativecommons.org/licenses/by-nc-nd/4.0
 

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