Synthesis, Characterization and Biological Evaluation of Newer Chalcones by Microwave irradiation

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Field Value
 
Title Synthesis, Characterization and Biological Evaluation of Newer Chalcones by Microwave irradiation
 
Creator Tupare, Shrikrishna
Pawar, Rajendra P.
 
Subject Pyridazine
Microwave
Chalcones
Antifungal
Antibacterial
Acetophenone
CHemistry
 
Description Chalcones are a common natural pigment & one of the most important classes of flavonoids & iso-flavonoids across the whole edible plant kingdom. This α, β- unsaturated carbonyl is an important and versatile intermediate for the preparation of various heterocycles. Their utility lies in their usefulness as synthons. Many research articles on chalcones were found in the literature. In this article, a series of pyridazine Chalcone derivatives were synthesized by Claisen-Schmidt condensation of 6-(3-Acetyl phenylamino) pyridazin-3(2H)-one with substituted benzaldehyde with potassium hydroxide in microwave assessed irradiation. All the synthesized derivatives(3a-o) were screened for their anti-bacterial and anti-fungal activities. Several compounds throughout the series showed moderate to good anti-bacterial and anti-fungal activity against human pathogens.
 
Publisher PURKH
 
Date 2020-12-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://purkh.com/index.php/tochem/article/view/915
 
Source To Chemistry Journal; Vol. 7 (2020); 150-162
2581-7507
 
Language eng
 
Relation https://purkh.com/index.php/tochem/article/view/915/842
 
Rights Copyright (c) 2020 Shrikrishna Tupare, Rajendra P. Pawar
https://creativecommons.org/licenses/by/4.0
 

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