Assessment of Usefulness of CRP, PMN Elastase, PCT and Il- 6 as Prognostic Factors in Patients with Acute Pancreatitis

Academia Journal of Surgery

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Title Assessment of Usefulness of CRP, PMN Elastase, PCT and Il- 6 as Prognostic Factors in Patients with Acute Pancreatitis
 
Creator B. Jagan Mohan Reddy
S.P. Girish
 
Subject Acute Pancreatitis
PMN-Elastase
Markers
 
Description Background: Acute pancreatitis is an inflammatory disease of the exocrine pancreas with rapid onset. The present study was conducted to assess the usefulness of CRP, PMN elastase, PCT and IL- 6 as prognostic factors in patients with acute pancreatitis. Subjects and Methods: The present study comprised 53 patients who presented with a diagnosis of Acute Pancreatitis. CRP was estimated by turbidimetric immunoassay using CRP/U2A-000 kit. PMN-Elastase was estimated by solid-phase enzyme immunoassay. Procalcitonin was estimated by the immuno- chromatographic test. IL-6 was estimated by Immuno-enzymatic assay. Results: There were 47 males and 6 females in the present study. The mean SD CRP in patients with mild pancreatitis was 44.35 53.04 and in severe pancreatitis was 174.80 14.55, PCT was seen in 4 in mild pancreatitis patients and 12 in severe pancreatitis patients, PMN- elastase level was 3.89 1087 in mild pancreatitis and 3.99 2.75 inn severe pancreatitis patients, IL-6 level was 129.63 319.08 in mild pancreatitis and 1166.76 818.06 in severe pancreatitis patients. The difference was significant (P< 0.05). CRP had higher (100) specificity as compared to PCT (81), PMN- E (10) and IL- 6 (90), Specificity found to be 88, 81, 97 and 94 respectively, PPV was 84, 74, 67 and 90 respectively, NPV was 100, 87, 62 and 94 respectively, accuracy was 92, 81, 62 and 92 respectively, AUC was 0.97, 0.81, 0.43 and 0.95 respectively. Conclusion: Authors found that CRP is the single best predictor of the severity of acute pancreatitis. IL-6 and PCT also are reliable predictors. PMN-Elastase needs to be assessed in patients with acute pancreatitis presenting early in the course of the illness.
 
Publisher Dr. Sanket Hiware, College of Medicine and Health Science, DireDawa University, Ethiopia.
 
Date 2020-12-27
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
application/xml
text/html
application/epub+zip
 
Identifier http://aijournals.com/index.php/ajs/article/view/1788
10.47008/ajs/2020.3.2.1
 
Source Academia Journal of Surgery; Vol 3 No 2 (2020): July-December 2020; 1-4
2663-8347
2663-8339
 
Language eng
 
Relation http://aijournals.com/index.php/ajs/article/view/1788/1841
http://aijournals.com/index.php/ajs/article/view/1788/1842
http://aijournals.com/index.php/ajs/article/view/1788/1843
http://aijournals.com/index.php/ajs/article/view/1788/1844
 
Rights Copyright (c) 2020 Author
https://creativecommons.org/licenses/by/4.0/
 

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