Iminosugar 1-Deoxynojirimycin (DNJ) sebagai Antiviral Infeksi Virus Dengue

Keluwih: Jurnal Kesehatan dan Kedokteran

View Publication Info
 
 
Field Value
 
Title Iminosugar 1-Deoxynojirimycin (DNJ) sebagai Antiviral Infeksi Virus Dengue
 
Creator Adnan, Muhammad Luthfi
 
Description Abstract— Dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) caused by the DENV virus are among the global problems regarding mosquito-borne viral infections. The DENV virus is transmitted through Aedes aegypti causing clinical manifestations that can cause critical illness for patients. The need for effective antiviral therapy is needed to treat DENV virus infections. 1-Deoxynojirimycin (DNJ), one of the many imino sugars found in mulberry leaves and several strains of bacteria, has potential as an antiviral against DENV virus infection. The antiviral activity of DNJ works as an inhibitor of the α-glucosidase enzyme which is important in virus secretion so that it affects the infection rate. DNJ also has the effect of boosting the immune system to initiate an immune response to a viral infection. Further research is needed to develop DNJ as an effective antiviral DENV in the future. Keywords: antiviral, dengue, iminosugar, therapy
Abstrak— Dengue fever (DF), dengue hemorraghic fever (DHF), dan dengue shock syndrome (DSS) yang disebabkan oleh virus DENV merupakan salah satu permasalahan global mengenai infeksi virus. Virus DENV ditularkan melalui Aedes aegypti menyebabkan manifestasi klinis yang dapat menimbulkan kesakiatn kritis bagi pasien. kebutuhan terapi antiviral yang efektif diperlukan untuk mengobati infeksi virus DENV. 1-Deoxynojirimycin (DNJ), salah satu iminosugar yang banyak terdapat pada daun mulberry dan beberapa strain bakteri, memiliki potensi sebagai antiviral terhadap infeksi virus DENV. Aktivitas antiviral DNJ bekerja sebagai penghambat enzim α-glukosidase yang penting dalam sekresi virus sehingga mempengaruhi tingkat infeksi. DNJ juga memiliki efek meningkatkan sistem imun untuk menginisiasi respon imun terhadap infeksi virus. Penelitian lebih lanjut diperlukan untuk mengembangkan DNJ sebagai antiviral DENV yang efektif di masa depan. Kata kunci: antiviral, dengue, iminosugar, therapy
 
Publisher Direktorat Penerbitan dan Publikasi Ilmiah, Universitas Surabaya
 
Date 2020-12-21
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier http://journal.ubaya.ac.id/index.php/kesdok/article/view/2970
10.24123/kesdok.V2i1.2970
 
Source KELUWIH: Jurnal Kesehatan dan Kedokteran; Vol 2 No 1 (2020): Keluwih: Jurnal Kesehatan dan Kedokteran (Desember); 56-63
2715-6419
10.24123/kesdok.v2i1
 
Language eng
 
Relation http://journal.ubaya.ac.id/index.php/kesdok/article/view/2970/3057
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library