Assessment of needle tip geometry during infusions into a brain phantom gel

Scientia et Technica Journal

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Field Value
 
Title Assessment of needle tip geometry during infusions into a brain phantom gel
 
Creator Orozco Grajales, Gustavo Alejandro
Casanova García, Fernando
García Álvarez, Jose Jaime
 
Description Convection-enhanced delivery (CED) is a promising method to deliver therapeutic drugs directly into the brain that has shown limited efficacy, mainly attributed to backflow, in which the infused drug flows back along the needle track rather than forward into tissue. This study evaluates the effect of sharp and blunt needle tips on backflow length under different flow rates via CED. Infusions were performed in a transparent 0.6% (w/v) brain phantom agarose hydrogel. Backflow length was significantly higher using sharp-tip needles for higher flow rates. No significant differences were observed between tip shapes for lower flow rates. In conclusion, sharp-tip needles present limitations for higher flow rates, which are needed to deliver more drug during shortest times.
Convection-enhanced delivery es una técnica para suministrar drogas directamente en el cerebro para el tratamiento de enfermedades del sistema nervioso central. Este método ha mostrado una limitada eficacia atribuida principalmente al fenómeno de backflow, en el cual, la sustancia fluye hacia atrás por fuera de la aguja en vez de alcanzar la región del tejido delante de la punta. Este estudio evalúa el efecto de los tipos de punta plana y biselada sobre el fenómeno de backflow bajo diferentes caudales. Las infusiones experimentales se realizaron en gel de agarosa transparente al 0.6% (w/v). La longitud de backflow fue significativamente mayor para infusiones con aguja biselada a caudales mayores. No se observaron diferencias significativas entre ambos tipos de aguja para caudales menores. En conclusión, agujas con punta biselada presentan limitaciones a mayores caudales, las cuales son requeridas para suministrar mayor cantidad de fármaco durante los procedimientos clínicos.
 
Publisher Universidad Tecnológica de Pereira
 
Date 2020-12-17
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://revistas.utp.edu.co/index.php/revistaciencia/article/view/21511
10.22517/23447214.21511
 
Source Scientia et Technica; Vol 25 No 4 (2020); 616-620
Scientia et Technica; Vol. 25 Núm. 4 (2020); 616-620
2344-7214
0122-1701
 
Language eng
 
Relation https://revistas.utp.edu.co/index.php/revistaciencia/article/view/21511/16478
 
Rights Derechos de autor 2020 Scientia et technica
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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