SERUM CONCENTRATION OF THYROID HORMONES AND THYROID STIMULATING HORMONE IN ALLOXAN-INDUCED TYPE 1 DIABETIC WISTAR ALBINO RATS

Gomal Journal of Medical Sciences

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Title SERUM CONCENTRATION OF THYROID HORMONES AND THYROID STIMULATING HORMONE IN ALLOXAN-INDUCED TYPE 1 DIABETIC WISTAR ALBINO RATS
 
Creator Zamir, Sher
Ijaz, Azhar
Umair, Muhammad
Wazir, Rahat Jan
Salman, Mohammad
Nazir, Aamir
 
Description Background: Literature has reported thyroid functional abnormalities in diabetes mellitus. The objectives of this study were to determine and compare the serum concentrations of T3, T4 and TSH in alloxan-induced type 1 diabetic and control Wistar albino rats.
Materials & Methods: It was an experimental animal study on 20 Wistar albino rats, extending over a period of eight weeks. Alloxan, a diabetogenic agent, was used to produce animal models of type 1 diabetes. Animals were divided equally into two groups: control and diabetic. The animals in the diabetic group were injected intraperitoneally with 150 mg/kg body weight of 10% alloxan to induce diabetes. After 72 hours, diabetes was confirmed with glucometer (glucose >350mg/dl). During the course of experiment, one rat in control group and 2 rats in diabetic group died. Blood was collected for estimation of serum concentrations of thyroid hormones, thyroid stimulating hormone at the end of experimental period. Serum T3, T4, and TSH were measured using ELISA kits.
Results: At the end of eight weeks, the mean concentration of serum T3 was 0.69 ±0.29 ng/ml and 0.44±0.02 ng/ml in control and diabetic groups, respectively. The mean concentration of T4 was
3.78±1.16 μg/dl and 2.24±0.86 μg/dl in control and diabetic groups respectively. The mean concentration of TSH was 0.77±0.20 μU/ml and 1.41±0.23 μU/ml in control and diabetic groups respectively. The mean serum concentrations of T3 (p=.0025) and T4 (p=
 
Publisher Gomal Medical College, D.I.Khan, Pakistan
 
Date 2019-12-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.gjms.com.pk/ojs24/index.php/gjms/article/view/2083
 
Source 1997-2067
1819-7973
 
Language eng
 
Relation http://www.gjms.com.pk/ojs24/index.php/gjms/article/view/2083/1313
http://www.gjms.com.pk/ojs24/index.php/gjms/article/downloadSuppFile/2083/594
 
Rights Copyright (c) 2019 Sher Zamir, Azhar Ijaz, Muhammad Umair, Rahat Jan Wazir, Aamir Nazir, Mohammad Salman
https://creativecommons.org/licenses/by-nc/4.0
 

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