Lysine analogue use during cancer surgery: a survey from a Canadian tertiary care centre

Current Oncology

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Title Lysine analogue use during cancer surgery: a survey from a Canadian tertiary care centre
Creator Montroy, J.
Hutton, B.
Fergusson, D.A.
Tinmouth, A.
Lavallée, L.T.
Cagiannos, I.
Morash, C.
Flaman, A.
Breau, R.H.
Subject surgery
lysine analogues
tranexamic acid
Description Background When used during surgery, antifibrinolytic hemostatic agents such as lysine analogues are effective at reducing blood loss and the need for transfusions. Despite proven efficacy, use of hemostatic agents remains low during some surgeries. Our objective was to explore surgeon opinions about, and use of lysine analogues in, oncologic surgeries at a large tertiary care academic institution.
Methods We administered a survey to surgeons who perform high-transfusion-risk oncologic surgeries at a large academic hospital in Ottawa, Ontario. Design and distribution of the survey followed a modified Dillman method. To ensure that the survey questionnaire was relevant, clear, and concise, we performed informant interviews, cog­nitive interviews, and pilot-testing. The final survey consisted of 19 questions divided into 3 sections: respondent demographics, use of hemostatic agents, and potential clinical trial opinions.
Results Of 28 surgeons, 24 (86%) participated. When asked to indicate the frequency of lysine analogue use, “never” accounted for 46% of the responses, and “rarely” (<10% of the time) accounted for 23% of the responses. Reasons for never using included “unfamiliar with benefits” and “prefer alternatives.” Fifteen surgeons (63%) felt that a trial was needed to demonstrate the efficacy and safety of lysine analogues in their cancer field.
Conclusions Our survey found that lysine analogues are infrequently used during oncologic surgeries at our institution. Many surgeons are unfamiliar with the benefits and side effects of lysine analogues and, alternatively, use topical hemostatic agents. Our results demonstrate that future trials exploring the efficacy and safety of lysine analogues in oncologic surgery are needed.
Publisher Multimed Inc.
Date 2020-08-06
Type info:eu-repo/semantics/article
Format application/pdf
Source Current Oncology; Vol. 27 No. 6 (2020)
Language eng
Rights Copyright (c) 2020 Current Oncology

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