Pre-transplant Marital status and Hematopoietic Cell Transplantation Outcomes

Current Oncology

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Title Pre-transplant Marital status and Hematopoietic Cell Transplantation Outcomes
Creator Tay, J.
Beattie, S.
Bredeson, C.
Brazauskas, R.
He, N.
Ahmed, I. A.
Aljurf, M.
Askar, M.
Atsuta, Y.
Badawy, S.
Barata, A.
Beitinjaneh, A.M.
Bhatt, N.S.
Buchbinder, D.
Cerny, J.
Ciurea, S.
D'Souza, A.
Dalal, J.
Farhadfar, N.
Freytes, C.O.
Ganguly, S.
Gergis, U.
Gerull, S.
Lazarus, H.M.
Hahn, T.
Hong, S.
Inamoto, Y.
Khera, N.
Kindwall-Keller, T.
Kamble, R.T.
Knight, J.M.
Koleva, Y.N.
Kumar, A.
Kwok, J.
Murthy, H.S.
Olsson, R.F.
Diaz-Perez, M. Angel
Rizzieri, D.
Seo, S.
Chhabra, S.
Schoemans, H.
Schouten, H.C.
Steinberg, A.
Sullivan, K.M.
Szer, J.
Szwajcer, D.
Ulrickson, M.L.
Verdonck, L.F.
Wirk, B.
Wood, W.A.
Yared, J.A.
Saber, W.
Subject Adenosquamous carcinoma
disease characteristics
Description Background
Evidence regarding the impact of pre-hematopoietic cell transplantation (HCT) marital status on post-HCT outcomes is conflicting.
We identified patients, ≥40-years within the Center for International Blood and Marrow Transplant Research registry who received a HCT between January 2008 and December 2015. Pre-HCT marital status was declared as either 1) Married/living with a partner, 2) Single/never married, 3) Separated/divorced, and 4) Widowed. We performed multivariable analysis to determine the association of marital stsatus with post-HCT outcomes.
We identified 10,226 allogeneic and 5,714 autologous HCT patients with a median follow-up of 37 months (range 1-102) and 40 months (range 1-106) respectively. There was no association between marital status and OS in both allogeneic (p=0.58) and autologous (p=0.17) settings. However, marital status was associated with grade 2-4 acute GVHD (p<0.001) and chronic GVHD (p=0.04). There was an increased risk of grade 2-4 acute GVHD in separated patients compared with married patients [HR 1.13, 95%CI (1.03-1.24)], while single patients had a reduced risk of grade 2-4 acute GVHD [HR 0.87, 95%CI (0.77-0.98)]. The risk of chronic GVHD was lower in widowed patients [HR 0.82, 95%CI (0.67-0.99)] compared with married patients.
OS post-HCT is not influenced by marital status, but there are associations between marital status and grade 2-4 acute and chronic GVHD. Future research should consider measuring social support using validated scales, patient and caregiver reports of caregiver commitment, and assess health-related quality of life together with health-care utilization to better appreciate the impact of marital status and social support.
Publisher Multimed Inc.
Date 2020-09-04
Type info:eu-repo/semantics/article
Format application/pdf
Source Current Oncology; Vol. 27 No. 6 (2020)
Language eng
Rights Copyright (c) 2020 Current Oncology

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