Comparison of transarterial bland and chemoembolization for neuroendocrine tumours: a systematic review and meta-analysis

Current Oncology

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Title Comparison of transarterial bland and chemoembolization for neuroendocrine tumours: a systematic review and meta-analysis
 
Creator Tai, E.
Kennedy, S.
Farrell, A.
Jaberi, A.
Kachura, J.
Beecroft, R.
 
Subject Neuroendocrine tumours
hepatic metastases
chemoembolization
bland embolization
 
Description Background Treatment of hepatic metastases from neuroendocrine tumours improves survival and symptom relief. Hepatic arterial embolotherapy techniques include transarterial chemoembolization (tace) and bland embo­lization (tae). The relative efficacy of the techniques is controversial. The purpose of the present study was to use a meta-analysis and systematic review to compare tace with tae in the treatment of hepatic metastases.
Methods A literature search identified studies comparing tace and tae for treatment of hepatic metastases. Out­comes of interest included overall survival (os), progression-free survival (pfs), radiographic response, complications, and symptom control. The hazard ratios (hrs) and odds ratios (ors) were estimated and pooled.
Results Eight studies and 504 patients were included. No statistically significant differences between tace and tae were observed for os at 1, 2, and 5 years or for hrs [1-year or: 0.72; 95% confidence interval (ci): 0.27 to 1.94; p < 0.52; 2-year or: 0.69; 95% ci: 0.43 to 1.11; p < 0.12; 5-year or: 0.91; 95% ci: 0.37 to 2.24; p < 0.85; hr: 0.96; 95% ci: 0.73 to 1.24; p < 0.74]. No statistically significant differences between tace and tae were observed for pfs at 1, 2, and 5 years or for hrs (1-year or: 0.71; 95% ci: 0.38 to 1.55; p < 0.30; 2-year or: 0.83; 95% ci: 0.33 to 2.06; p < 0.69; 5-year or: 0. 91; 95% ci: 0.37 to 2.24; p < 0.85; hr: 0.99–1.74; 95% ci: 0.74 to 1.73; p < 0.97). Both techniques are safe and effective for symptom control.
Conclusions No statistically significant differences between tace and tae were observed for os and pfs.
 
Publisher Multimed Inc.
 
Date 2020-09-02
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
application/pdf
text/html
 
Identifier http://www.current-oncology.com/index.php/oncology/article/view/6205
10.3747/co.27.6205
 
Source Current Oncology; Vol. 27 No. 6 (2020)
1718-7729
1198-0052
 
Language eng
 
Relation http://www.current-oncology.com/index.php/oncology/article/view/6205/9627
http://www.current-oncology.com/index.php/oncology/article/view/6205/9503
http://www.current-oncology.com/index.php/oncology/article/view/6205/9691
 
Rights Copyright (c) 2020 Current Oncology
 

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