Antimalarial Activity, Phytochemical Composition and Acute Toxicity Tests of Ethanolic Stem Bark Extract of Alstonia boonei De Wild

International Journal of Pathogen Research

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Title Antimalarial Activity, Phytochemical Composition and Acute Toxicity Tests of Ethanolic Stem Bark Extract of Alstonia boonei De Wild
 
Creator Otuu, Chidiebere A.
Obiezue, Rose N. N.
Okoye, Chris I.
Omalu, Innocent C. J.
Otuu, Ada Q. A.
Eke, Samuel S.
Udeh, Emmanuel. O.
Ekuma, Innocent C.
Yamman, Hadijah U.
Okafor, Fabian C.
 
Description Many modern medicines are derived from the chemicals available in plants. The utilization of plants against diseases by traditional medical practitioners is common in many parts of the world and several researches have been carried out to determine the scientific basis for the use of such plants. Alstonia boonei is one of the many medicinal plants found in Nigeria. The plant parts have been traditionally used to treat various ailments including malaria. This study was carried out to evaluate the antimalarial activity, phytochemical composition and toxicity of ethanolic stem bark extract of Alstonia boonei. The extract showed substantial dose dependent antimalarial activity as indicated by the recorded suppressive (45.67%, 58.53% and 74.68% for 100, 200 and 400 mgkg-1 body weights) prophylactic (33.57%, 45.64% and 61.23% for 100, 200 and 400 mgkg-1 body weights) and curative effects (62.35%, 68.57% and 79.63% for 100, 200 and 400 mgkg-1 body weights) on Plasmodium berghei infected white albino mice. The results of the antimalarial tests were significantly different compared to the negative control at P < 0.05. The phytochemical evaluation showed that the plant contained important chemical compounds including tannins, flavonoids, steroids, phenols, alkaloids, saponins, glycosides and terpenoids. The acute toxicity test showed that the extract is safe as observed on the tested mice. It was concluded that the extract contains important active antimalarial compounds that are safe and should be further investigated for antimalarial drug development.
 
Publisher International Journal of Pathogen Research
 
Date 2020-12-16
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier http://journalijpr.com/index.php/IJPR/article/view/30144
10.9734/ijpr/2020/v5i430144
 
Source International Journal of Pathogen Research; 2020 - Volume 5 [Issue 4]; 55-63
2582-3876
 
Language eng
 
Relation http://journalijpr.com/index.php/IJPR/article/view/30144/56564
http://journalijpr.com/index.php/IJPR/article/view/30144/56565
 
Rights Copyright (c) 2020 © 2020 Otuu et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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