A comprehensive medical approach to gestational trophoblastic disease: A Clinical Case Report

Revista Arbitrada Interdisciplinaria de Ciencias de la Salud. Salud y Vida.

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Title A comprehensive medical approach to gestational trophoblastic disease: A Clinical Case Report
Enfoque médico integral de la enfermedad trofoblástica gestacional: Reporte de un Caso Clínico
 
Creator Sangucho-Verdezoto., Pedro Ángel
López-Guerrero, Ana Abigail
Escobar-Martínez, María Margarita
Plasencia-Criollo, Jenny Irene
 
Subject Health Sciences
Uterine neoplasms; family practice; public health.
Ciencias de la Salud
Neoplasias uterinas; medicina familiar y comunitaria; salud pública.
 
Description Daily medical practice must always be carried out in a comprehensive manner at all levels of care of the National Health System. Objective: Analysis of a case of gestational trophoblastic neoplasia, giving it a comprehensive approach from the perspective of a Family Medicine Specialist. Methodology: presentation of a clinical case, descriptive observational. Results: Gestational trophoblastic disease is an uncommon pathology, a small percentage of diagnosed cases (2%), can become a malignant disease from a clinical and histopathological point of view, choriocarcinoma more frequently. Conclusions: This clinical case treats a gestational trophoblastic neoplasia, which developed in an adolescent woman, primigravida, with no personal or family pathological history of importance. However, there are social, family and cultural considerations that must also be taken into account for hospital management.
La práctica médica diaria, siempre debe ser ejecutada de una manera integral en todos los niveles de atención del Sistema Nacional de Salud. Objetivo: Análisis de caso de neoplasia trofoblástica gestacional, dándole un enfoque integral desde la visión de un Especialista en Medicina Familiar. Metodología: presentación de caso clínico, observacional descriptivo. Resultados: La enfermedad trofoblástica gestacional es una patología poco frecuente, un pequeño porcentaje de los casos diagnosticados (2%), pueden convertirse desde el punto de vista clínico e histopatológico en una enfermedad maligna, el coriocarcinoma con mayor frecuencia. Conclusiones: Éste caso clínico trata una neoplasia trofoblástica gestacional, que desarrolló en una mujer adolescente, primigesta, sin antecedentes patológicos personales, ni familiares de importancia. Sin embargo, existen consideraciones sociales, familiares y culturales que también deben ser tomadas en cuenta para el manejo hospitalario.
 
Publisher Fundación Koinonia
 
Contributor

 
Date 2020-11-03
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artículo evaluado por pares
 
Format text/html
application/pdf
 
Identifier http://fundacionkoinonia.com.ve/ojs/index.php/saludyvida/article/view/1009
10.35381/s.v.v4i8.1009
 
Source Revista Arbitrada Interdisciplinaria de Ciencias de la Salud. Salud y Vida; Vol. 4, Núm. 8 (4): Julio - Diciembre. 2020; 185-199
2610-8038
10.35381/s.v.v4i8
 
Language spa
 
Relation http://fundacionkoinonia.com.ve/ojs/index.php/saludyvida/article/view/1009/html
http://fundacionkoinonia.com.ve/ojs/index.php/saludyvida/article/view/1009/pdf
/*ref*/Seckl MJ, Sebire NJ, Berkowitz RS. Gestational trophoblastic disease. Lancet. 2010 Aug 28;376 (9742):717-29. doi: 10.1016/S0140-6736(10)60280-2. Epub 2010 Jul 29. PMID: 20673583.
/*ref*/Lima LLA, Padron L, Câmara R, Sun SY, Rezende J Filho, Braga A. The role of surgery in the management of women with gestational trophoblastic disease. Rev Col Bras Cir. 2017 Jan-Feb;44(1):94-101. English, Portuguese. doi: 10.1590/0100-69912017001009. PMID: 28489216.
/*ref*/López CL, Lopes VGS, Resende FR, Steim JL, Padrón L, Sun SY, Araujo Júnior E, Braga A. Gestational Trophoblastic Neoplasia after Ectopic Molar Pregnancy: Clinical, Diagnostic, and Therapeutic Aspects. Rev Bras Ginecol Obstet. 2018 May;40(5):294-299. English. doi: 10.1055/s-0038-1653976. Epub 2018 May 16. PMID: 29768638.
/*ref*/Berkowitz RS, Goldstein DP. Clinical practice. Molar pregnancy. N Engl J Med. 2009 Apr 16;360(16):1639-45. doi: 10.1056/NEJMcp0900696. PMID: 19369669.
/*ref*/Andrijono A, Muhilal M. Prevention of post-mole malignant trophoblastic disease with vitamin A. Asian Pac J Cancer Prev. 2010;11(2):567-70. PMID: 20843153.
/*ref*/van Trommel NE, Massuger LF, Schijf CP, ten Kate-Booij MJ, Sweep FC, Thomas CM. Early identification of resistance to first-line single-agent methotrexate in patients with persistent trophoblastic disease. J Clin Oncol. 2006 Jan 1;24(1):52-8. doi: 10.1200/JCO.2005.03.3043. PMID: 16382113.
/*ref*/van Trommel NE, Thomas CM, Massuger LF, Sweep FC. Second curettage in persistent trophoblastic disease (PTD): the need for univocal definition of PTD. Gynecol Oncol. 2005 Oct;99(1):250-1; author reply 251. doi: 10.1016/j.ygyno.2005.03.012. PMID: 16224821.
/*ref*/Pezeshki M, Hancock BW, Silcocks P, Everard JE, Coleman J, Gillespie AM, Tidy J, Coleman RE. The role of repeat uterine evacuation in the management of persistent gestational trophoblastic disease. Gynecol Oncol. 2004 Dec;95(3):423-9. doi: 10.1016/j.ygyno.2004.08.045. PMID: 15581942.
/*ref*/Maestá I, Braga A. Desafios do tratamento de pacientes com doença trofoblástica gestacional [Challenges of the treatment of patients with gestational trophoblastic disease]. Rev Bras Ginecol Obstet. 2012 Apr;34(4):143-6. Portuguese. PMID: 22584808.
/*ref*/Tidy JA, Gillespie AM, Bright N, Radstone CR, Coleman RE, Hancock BW. Gestational trophoblastic disease: a study of mode of evacuation and subsequent need for treatment with chemotherapy. Gynecol Oncol. 2000 Sep;78(3 Pt 1):309-12. doi: 10.1006/gyno.2000.5839. PMID: 10985885.
/*ref*/Mangili G, Lorusso D, Brown J, Pfisterer J, Massuger L, Vaughan M, Ngan HY, Golfier F, Sekharan PK, Charry RC, Poveda A, Kim JW, Xiang Y, Berkowtiz R, Seckl MJ. Trophoblastic disease review for diagnosis and management: a joint report from the International Society for the Study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup. Int J Gynecol Cancer. 2014 Nov;24(9 Suppl 3):S109-16. doi: 10.1097/IGC.0000000000000294. PMID: 25341573.
/*ref*/Seckl MJ, Sebire NJ, Fisher RA, Golfier F, Massuger L, Sessa C; ESMO Guidelines Working Group. Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013 Oct;24 Suppl 6:vi39-50. doi: 10.1093/annonc/mdt345. Epub 2013 Sep 1. PMID: 23999759.
/*ref*/Bolze PA, Attia J, Massardier J, Seckl MJ, Massuger L, van Trommel N, Niemann I, Hajri T, Schott AM, Golfier F; EOTTD group. Formalised consensus of the European Organisation for Treatment of Trophoblastic Diseases on management of gestational trophoblastic diseases. Eur J Cancer. 2015 Sep;51(13):1725-31. doi: 10.1016/j.ejca.2015.05.026. Epub 2015 Jun 16. PMID: 26092638.
/*ref*/Rivera Domínguez A, Mora Jurado A, García de la Oliva A, de Araujo Martins-Romeo D, Cueto Álvarez L. Gynecological pelvic pain as emergency pathology. Radiologia. 2017 Mar-Apr;59(2):115-127. English, Spanish. doi: 10.1016/j.rx.2016.09.010. Epub 2016 Dec 12. PMID: 27979433.
/*ref*/Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L. Update on the diagnosis and management of gestational trophoblastic disease. Int J Gynaecol Obstet. 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586.
/*ref*/Espinoza AA, Fernández VR, Solar VT. Update in gestational trophoblastic pathology: hydatidiform mole and neoplasias. Revista Médica Sinergia. 2019;4(05):44-59.
/*ref*/Ning F, Hou H, Morse AN, Lash GE. Understanding and management of gestational trophoblastic disease. F1000Res. 2019 Apr 10;8:F1000 Faculty Rev-428. doi: 10.12688/f1000research.14953.1. PMID: 31001418; PMCID: PMC6464061.
/*ref*/Melamed A, Gockley AA, Joseph NT, Sun SY, Clapp MA, Goldstein DP, Berkowitz RS, Horowitz NS. Effect of race/ethnicity on risk of complete and partial molar pregnancy after adjustment for age. Gynecol Oncol. 2016 Oct;143(1):73-76. doi: 10.1016/j.ygyno.2016.07.117. Epub 2016 Jul 30. PMID: 27486130.
/*ref*/Shaaban AM, Rezvani M, Haroun RR, Kennedy AM, Elsayes KM, Olpin JD, Salama ME, Foster BR, Menias CO. Gestational Trophoblastic Disease: Clinical and Imaging Features. Radiographics. 2017 Mar-Apr;37(2):681-700. doi: 10.1148/rg.2017160140. PMID: 28287945.
/*ref*/Kaur B, Short D, Fisher RA, Savage PM, Seckl MJ, Sebire NJ. Atypical placental site nodule (APSN) and association with malignant gestational trophoblastic disease; a clinicopathologic study of 21 cases. Int J Gynecol Pathol. 2015 Mar;34(2):152-8. doi: 10.1097/PGP.0000000000000128. PMID: 25675185.
/*ref*/Mangili G, Sigismondi C, Lorusso D, Cormio G, Candiani M, Scarfone G, Mascilini F, Gadducci A, Mosconi AM, Scollo P, Cassani C, Pignata S, Ferrandina G. The role of staging and adjuvant chemotherapy in stage I malignant ovarian germ cell tumors (MOGTs): the MITO-9 study. Ann Oncol. 2017 Feb 1;28(2):333-338. doi: 10.1093/annonc/mdw563. PMID: 27803008.
/*ref*/Frijstein MM, Lok CAR, van Trommel NE, Ten Kate-Booij MJ, Massuger LFAG, van Werkhoven E, Kaur B, Tidy JA, Sarwar N, Golfier F, Winter MC, Hancock BW, Seckl MJ; all the contributors to the ISSTD PSTT/ETT database. Management and prognostic factors of epithelioid trophoblastic tumors: Results from the International Society for the Study of Trophoblastic Diseases database. Gynecol Oncol. 2019 Feb;152(2):361-367. doi: 10.1016/j.ygyno.2018.11.015. Epub 2018 Nov 22. PMID: 30473257.
/*ref*/Irigoyen-Coria A, Vázquez-Martínez VH, Arévalo-Ramírez LA. Influencia de los médicos de Tamaulipas en el desarrollo de la Medicina Familiar en México y Latinoamérica. Aten Fam. 2016;23(1):1-3.
/*ref*/Martín Zurro A y cols. Compendio de Atención primaria. Conceptos, organización y práctica clínica en Medicina de Familia. 4th Ed. Barcelona: Elsevier; 2016.
/*ref*/Varela-Rueda CE, Reyes-Morales H, Albavera-Hernández C, et al. La medicina familiar en México: presente y futuro. Gac Med Mex. 2016;152(1):135-140.
/*ref*/De la Cruz-Florencio P, Godínez-Tamay ED, Hernández-Miranda MB. La Medicina Familiar como especialidad médica: percepción de otros especialistas. Aten Fam. 2016;23(3):109-112.
/*ref*/Sánchez Hidalgo Md. La familia como objeto de investigación: un reto para los profesionales de la salud. RM [revista en Internet]. 2016; 20(5): [aprox. 4 p.].
/*ref*/Sandoval M, Holme F, Lobo S, Slavkovsky R, Thomson KA, Jeronimo J, Figueroa J, Sanjose S. Age patterns of human papillomavirus infection as primary screening test for cervical cancer and subsequent triage with visual inspection in Honduras. Salud Publica Mex. 2020 Sep-Oct;62(5):487-493. English. doi: 10.21149/10979. Epub 2020 Jul 15. PMID: 32697901.
/*ref*/Flores-Pulido JJ, Martínez-Correa M. Cáncer cervicouterino y virus del papiloma humano. Una mirada desde el enfoque médico familiar [Cervical cancer and human papillomavirus. A glance from a family medical viewpoint]. Rev Med Inst Mex Seguro Soc. 2015;53 Suppl 2:S162-4. Spanish. PMID: 26462511.
/*ref*/Pérez Pérez Alvaro, Gonzáles Moreno Ivian Zoila, Rodríguez Larralde Raúl Lázaro, Terrero Quiala Lisbet. Agregación familiar para cáncer de cuello uterino. Rev Cubana Med Gen Integr [Internet]. 2019 Dic ; 35(4): e881.
 
Rights Copyright (c) 2020 Pedro Ángel Sangucho-Verdezoto., Ana Abigail López-Guerrero, María Margarita Escobar-Martínez, Jenny Irene Plasencia-Criollo
http://creativecommons.org/licenses/by-nc-sa/4.0
 

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