A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE

JOURNAL OF ADVANCES IN CHEMISTRY

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Title A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE
 
Creator Zaki, Dr Remon M
Kamal El-Dean, Prof Adel M.
Marzouk, Dr Nermin A
Micky, Prof Jehan A
Ahmed, Mrs Rasha H
 
Description  Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f  which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound 7-16. All the newly synthesized compounds were established by elemental and spectral analysis (IR, 1H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.
 
Publisher CIRWORLD
 
Date 2015-10-26
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://cirworld.com/index.php/jac/article/view/845
 
Source JOURNAL OF ADVANCES IN CHEMISTRY; Vol 12 No 1; 3910-3918
2321-807X
 
Language eng
 
Relation http://cirworld.com/index.php/jac/article/view/845/825
 
Rights Copyright (c) 2016 JOURNAL OF ADVANCES IN CHEMISTRY
 

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