4-(3,4-Dichlorophenyl)-6-(Furan-2-yl)Pyrimidine-2-Thiol as Building Block in Heterocyclic Synthesis
JOURNAL OF ADVANCES IN CHEMISTRY
View Publication Info| Field | Value | |
| Title |
4-(3,4-Dichlorophenyl)-6-(Furan-2-yl)Pyrimidine-2-Thiol as Building Block in Heterocyclic Synthesis
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| Creator |
EL-Hashash, M. A.
El-badry, Yaser Abdel-moemen Morsy, J. M. |
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| Subject |
Hydrazinylpyrimidine; Oxadiazolo-pyrimidine; Pyrazolo-pyrimidine; Thioxopyrimidine; Triazolo-pyrimidine.
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| Description |
Pyrimidine-2-thiol (1) has been synthesized via one-pot, three component synthesis. Its behavior towards nitrogen nucleophiles like hydrazine hydrate, ethylamine, piperidine, and 2-aminobenzoic acid has been studied. A speculation to explain the activities of the thioamide-iminothiol equilibrium based on their thermodynamic and kinetic control under the experimental conditions were investigated. The hydrazinopyrimidine 2 and aminocarbamoyl derivative 8 were used as key starting materials for synthesis of some interesting nitrogen bridgehead compounds 10-13, hydrazones 14-16, and some mixed and non-mixed heterocyclic systems 17-19 respectively.
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| Publisher |
CIRWORLD
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| Date |
2009-09-17
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
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| Format |
application/pdf
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| Identifier |
http://cirworld.com/index.php/jac/article/view/2656
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| Source |
JOURNAL OF ADVANCES IN CHEMISTRY; Vol 5 No 2; 669-677
2321-807X |
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| Language |
eng
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| Relation |
http://cirworld.com/index.php/jac/article/view/2656/2580
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| Rights |
Copyright (c) 2013 Journal of Advances in Chemistry
http://creativecommons.org/licenses/by/4.0 |
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