A Convenient Synthesis of new Phenanthrolinone and Naphthyridinone Derivatives: Evaluation of their Biological activity

JOURNAL OF ADVANCES IN CHEMISTRY

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Field Value
 
Title A Convenient Synthesis of new Phenanthrolinone and Naphthyridinone Derivatives: Evaluation of their Biological activity
 
Creator Hosny, Mona A.
Mokbel, Wafaa A.
El-Sawi, Emtithal A.
 
Subject Smiles rearrangement; phenanthrolinone and naphthyridinone
 
Description A novel and effective synthesis of substituted acetamide via smiles rearrangement is described. Treatment of phenols with 2-chloroacetamide in the presence of sodium hydroxide and DMA where substituted phenols, which contain electron withdrawing groups, are more reactive for smiles rearrangement. The reaction followed by cyclization of the product by E.A.A. afforded the corresponding substituted phenanthrolinone and naphthyridinone in good yields and showed higher activity against (G- and G+, Eschierchia coli and Staphylococcus aureus respectively) and good activity toward Aspergillius flavus and Candida albicans.
 
Publisher CIRWORLD
 
Date 2014-04-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://cirworld.com/index.php/jac/article/view/4200
 
Source JOURNAL OF ADVANCES IN CHEMISTRY; Vol 9 No 1; 1866-1872
2321-807X
 
Language eng
 
Relation http://cirworld.com/index.php/jac/article/view/4200/5364
 
Rights Copyright (c) 2014 Journal of Advances in Chemistry
http://creativecommons.org/licenses/by/4.0
 

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