Natural Compound against COVID-19 in Silico Screening by Attacking Mpro and ACE2 Using Molecular Docking
International Journal for Research in Applied Sciences and Biotechnology
View Publication Info| Field | Value | |
| Title |
Natural Compound against COVID-19 in Silico Screening by Attacking Mpro and ACE2 Using Molecular Docking
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| Creator |
Dhiraj Kumar
Sanjana Bhagat |
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| Subject |
Covid
SARS-CoV-2 Coronavirus Auto-docking Phytochemicals Mpro ACE2 |
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| Description |
OBJECTIVE: At present, Coronavirus is spreading overall fastly and its control is troublesome on the grounds that there is no powerful antibody or medications accessible in blemish kets. This infection can taint the two creatures and people and cause diseases of the respiratory plot. WHO has pronounced Covid as pandemic and the entire world is battling against Covid. Worldwide, in excess of 199,478 individuals have been determined to have Coronavirus. As of Walk 18, 2020, in excess of 167 nations have been influenced and in excess of 8000 passings have been report-ed. The fundamental nation being influenced is China, followed by Italy, Iran, Spain, France and the USA. MATERIALS AND TECHNIQUES: Since there are no powerful medications accessible against Covid, we directed virtual screening of phytochemicals to discover novel mixes against this infection. Thus, we made a phytochemical library of 19 phytochemicals from 19 plants, which have been accounted for as antiviral, antibacterial and antifungal action. The phytochemical library was exposed to virtual screening against sub-atomic targets, Principle protease (Mpro) and Angiotensin-Changing over Compound 2 (ACE2). ENDS: In light of the coupling energy score, we recommend that these mixes can be tried against Covid and used to create successful antiviral medications. |
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| Publisher |
Vandana Publications
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| Date |
2020-11-30
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
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| Format |
application/pdf
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| Identifier |
https://www.ijrasb.com/ojs/index.php/ojs-ijrasb/article/view/221
10.31033/ijrasb.7.6.25 |
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| Source |
International Journal for Research in Applied Sciences and Biotechnology; Vol. 7 No. 6 (2020): November Issue; 168-180
2349-8889 |
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| Language |
eng
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| Relation |
https://www.ijrasb.com/ojs/index.php/ojs-ijrasb/article/view/221/180
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| Rights |
Copyright (c) 2020 International Journal for Research in Applied Sciences and Biotechnology
https://creativecommons.org/licenses/by-nc-nd/4.0 |
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