A cost-minimization analysis of combination therapy in hypertension: fixed-dose vs extemporary combinations

Farmeconomia. Health economics and therapeutic pathways

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Field Value
 
Title A cost-minimization analysis of combination therapy in hypertension: fixed-dose vs extemporary combinations
 
Creator Bellone, Marco
Sbarra, Pierluigi
 
Subject
Hypertension, Fixed-dose combinations, Cost-minimization analysis
 
Description BACKGROUND: Cardiovascular disease management and prevention represent the leading cost driver in Italian healthcare expenditure. In order to reach the target blood pressure, a large majority of patients require simultaneous administration of multiple antihypertensive agents.OBJECTIVE: To assess the economic impact of the use of fixed dose combinations of antihypertensive agents, compared to the extemporary combination of the same principles.METHODS: A cost minimization analysis was conducted to determine the pharmaceutical daily cost of five fixed dose combinations (olmesartan 20 mg + amlodipine 5 mg, perindopril 5 mg + amlodipine 5 mg, enalapril 20 mg + lercanidipine 10 mg, felodipine 5 mg + ramipril 5 mg, and delapril 30 mg + manidipine 10 mg) compared with extemporary combination of the same principles in the perspective of the Italian NHS. Daily acquisition costs are estimated based on current Italian prices and tariffs.RESULTS: In three cases the use of fixed‑dose combination instead of extemporary combination induces a lower daily cost. Fixed combination treatment with delapril 30 mg + manidipine 10 mg induces greater cost savings for the National Health System (95,47 €/pts/year), as compared to free drugs combination therapy.CONCLUSIONS: Compared with free drug combinations, fixed‑dose combinations of antihypertensive agents are associated with lower daily National Health Service acquisition costs.
 
Publisher SEEd Medical Publishers
 
Contributor Il presente lavoro è stato realizzato con il supporto di Bracco
 
Date 2013-12-18
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format text/html
application/pdf
 
Identifier https://journals.edizioniseed.it/index.php/FE/article/view/886
10.7175/fe.v14i4.886
 
Source Farmeconomia. Health economics and therapeutic pathways; Vol 14, No 4 (2013); 153-160
2240-256X
1721-6915
 
Language eng
 
Relation https://journals.edizioniseed.it/index.php/FE/article/view/886/1022
https://journals.edizioniseed.it/index.php/FE/article/view/886/1023
 
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Rights Copyright (c) 2013 Farmeconomia. Health economics and therapeutic pathways
http://creativecommons.org/licenses/by-nc/4.0
 

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