Evaluation of oxidative stress and cardiometabolic profile in hypothyroidism children

Cadernos de Campo: Revista de Ciências Sociais

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Title Evaluation of oxidative stress and cardiometabolic profile in hypothyroidism children
Creator Dudeja, Usha
Saxena, Rahul
Description Background: Despite massive efforts, oxidative stress along with abnormality in cardiometabolic profile is a serious concern in children and adolescent. However, in this context, limited studies have been documented in hypothyroidism (HT) young patients.
Aim: The objective of present study was to determine the oxidative stress and metabolic profile (glycemic and lipid profile) in young hypothyroidism patients and to determine their role in disease complexity.
Material & Method: Fasting blood glucose, serum insulin, thyroid and lipid profile (serum total cholesterol, triglycerides, HDL, LDL and VLDL levels) along with marker of lipid peroxidation (malondialdehyde; MDA) were estimated by using standard methods in 25 patients of HT as Group II, and compared it with 25 age matched young healthy controls (Group I). The values were expressed as Mean ± SD and data from patients and controls were compared using students‘t’ test.
Result: Fasting blood glucose, serum insulin, total cholesterol, triglycerides, LDL and VLDL levels along with MDA levels were significantly high (p<0.001) and serum HDL levels were significantly low (p<0.001) in patient group as compared to control group. These finding suggest that young HT patients are at enhanced risk to develop cardiovascular complication due to their altered lipid profile, insulin resistance and enhanced oxidative stress.
Conclusion: Therefore, regular screening of metabolic profiles, cardiac markers, control on oxidative stress and proper treatment of dyslipidemia along with maintenance of normal thyroid profile are necessary predictive and preventive measures which may help in reduction of CVD complications and its burden in the growing young population.
Publisher Scholar Science Journals
Date 2019-11-03
Type info:eu-repo/semantics/article
Peer-reviewed Article
Format application/pdf
Identifier https://ssjournals.com/index.php/ijbr/article/view/5263
Source International Journal of Biomedical Research; Vol 10 No 10 (2019): Oct; e5263
Language eng
Relation https://ssjournals.com/index.php/ijbr/article/view/5263/3572
Rights Copyright (c) 2019 International Journal of Biomedical Research

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