A Comparison of the Effects of Dexmedetomidine and Propofol in Controlling the Hemodynamic Responses after Intubation: A Double-Blind, Randomized, Clinical Trial Study

Open Access Macedonian Journal of Medical Sciences

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Title A Comparison of the Effects of Dexmedetomidine and Propofol in Controlling the Hemodynamic Responses after Intubation: A Double-Blind, Randomized, Clinical Trial Study
 
Creator Kamali, Alireza
Taghizadeh, Mehrdad
Esfandiar, Mohtaram
Akhtari, Amin Shams
 
Subject Dexmedetomidine; Propofol
Hemodynamic responses
intubation
 
Description AIM: This study aimed to compare the effects of dexmedetomidine and propofol in controlling the hemodynamic response following intubation of patients’ candidate intubation in the emergency department
METHODS: A total of 114 patients were randomly assigned to one of 2 groups to receive one of the following treatments: dexmedetomidine 0.4 µg/kg (Group D, n = 57) and propofol 1–1.5 mg/kg/h (Group P, n = 57). Hemodynamic data such as the systolic blood pressure, diastolic blood pressure, arterial oxygen saturation and heart rate (HR) were recorded from the entrance to operation room to 5, 10 and 15 min after tracheal intubation
RESULTS: Compared with group D, group P exhibited increases in mean arterial blood pressure (MAP), and systolic blood pressure significantly at all times and immediately after the endotracheal intubation. Moreover, the mean diastolic blood pressure changes due to tracheal intubation in group P were significantly more than group D immediately after the intubation. Furthermore, the mean heart rate changes immediately and 5 min after tracheal intubation was significantly higher in group P
CONCLUSION: Our data suggest that the benefits of dexmedetomidine more than propofol in hemodynamic stability because propofol was associated with more variability in systolic/diastolic blood pressure, HR and MAP after endotracheal intubation.
 
Publisher Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia
 
Date 2018-11-10
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
application/pdf
 
Identifier https://www.id-press.eu/mjms/article/view/oamjms.2018.385
10.3889/oamjms.2018.385
 
Source Open Access Macedonian Journal of Medical Sciences; Vol. 6 No. 11 (2018): Nov 25 (OAMJMS); 2045-2050
1857-9655
 
Language eng
 
Relation https://www.id-press.eu/mjms/article/view/oamjms.2018.385/2639
https://www.id-press.eu/mjms/article/view/oamjms.2018.385/2557
 
Rights Copyright (c) 2018 Alireza Kamali, Mehrdad Taghizadeh, Mohtaram Esfandiar, Amin Shams Akhtari
https://creativecommons.org/licenses/by-nc/4.0
 

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