Novel 3,5-Diaryl-4,5-dihydro-1H-pyrazole Derivatives: Synthesis, Antioxidant, Antimicrobial and Docking Study Against Glucosamine-6-phosphate Synthase
To Chemistry Journal
View Publication Info| Field | Value | |
| Title |
Novel 3,5-Diaryl-4,5-dihydro-1H-pyrazole Derivatives: Synthesis, Antioxidant, Antimicrobial and Docking Study Against Glucosamine-6-phosphate Synthase
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| Creator |
Ahmed Mutanabbi Abdula
Ban Hasan Taresh Mustafa Taha Mohammed Salah M Baqer Mohammed A. AL-Jaleel Khalil Ali Hameed Rasheed |
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| Subject |
docking study
antioxidant antimicrobial Pyrazoline Organic and Medicinal Chemistry |
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| Description |
In our attempt to exploring a new class of antimicrobial and antioxidant agents, novel 4,5-dihydro-1H-pyrazole derivatives were synthesized and characterized by some spectroscopic methods such as FTIR, 1HNMR, and GCMS. The antioxidant property for all the synthesized derivatives against DPPH radical was examined using TLC autographic assay then the scavenging activity was determined using the spectroscopic method. The antimicrobial study against several bacterial species (gram +ve and gram –ve) as well as candida Albicans of the potent hits, which exhibited the highest scavenging activity, was determined using a good diffusion method. The docking approach was used to explain the binding affinity of the lead hit four inside the binding site of Glucosamine-6-phosphate Synthase, the target enzyme for the antimicrobial agents.
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| Publisher |
PURKH
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| Date |
2020-08-15
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
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| Format |
application/pdf
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| Identifier |
https://purkh.com/index.php/tochem/article/view/709
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| Source |
To Chemistry Journal; Vol. 6: May - August 2020; 175-183
2581-7507 |
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| Language |
eng
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| Relation |
https://purkh.com/index.php/tochem/article/view/709/778
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| Rights |
Copyright (c) 2020 Ahmed Mutanabbi Abdula, Ban Hasan Taresh, Mustafa Taha Mohammed, Salah M Baqer, Mohammed A. AL-Jaleel Khalil, Ali Hameed Rasheed
https://creativecommons.org/licenses/by/4.0 |
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