Novel 3,5-Diaryl-4,5-dihydro-1H-pyrazole Derivatives: Synthesis, Antioxidant, Antimicrobial and Docking Study Against Glucosamine-6-phosphate Synthase

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Title Novel 3,5-Diaryl-4,5-dihydro-1H-pyrazole Derivatives: Synthesis, Antioxidant, Antimicrobial and Docking Study Against Glucosamine-6-phosphate Synthase
 
Creator Ahmed Mutanabbi Abdula
Ban Hasan Taresh
Mustafa Taha Mohammed
Salah M Baqer
Mohammed A. AL-Jaleel Khalil
Ali Hameed Rasheed
 
Subject docking study
antioxidant
antimicrobial
Pyrazoline
Organic and Medicinal Chemistry
 
Description In our attempt to exploring a new class of antimicrobial and antioxidant agents, novel 4,5-dihydro-1H-pyrazole derivatives were synthesized and characterized by some spectroscopic methods such as FTIR, 1HNMR, and GCMS. The antioxidant property for all the synthesized derivatives against DPPH radical was examined using TLC autographic assay then the scavenging activity was determined using the spectroscopic method. The antimicrobial study against several bacterial species (gram +ve and gram –ve) as well as candida Albicans of the potent hits, which exhibited the highest scavenging activity, was determined using a good diffusion method. The docking approach was used to explain the binding affinity of the lead hit four inside the binding site of Glucosamine-6-phosphate Synthase, the target enzyme for the antimicrobial agents.
 
Publisher PURKH
 
Date 2020-08-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://purkh.com/index.php/tochem/article/view/709
 
Source To Chemistry Journal; Vol. 6: May - August 2020; 175-183
2581-7507
 
Language eng
 
Relation https://purkh.com/index.php/tochem/article/view/709/778
 
Rights Copyright (c) 2020 Ahmed Mutanabbi Abdula, Ban Hasan Taresh, Mustafa Taha Mohammed, Salah M Baqer, Mohammed A. AL-Jaleel Khalil, Ali Hameed Rasheed
https://creativecommons.org/licenses/by/4.0
 

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