Malarial Related Myopathies: A Rhabdomyolysis Story

International Journal of Pathogen Research

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Title Malarial Related Myopathies: A Rhabdomyolysis Story
Creator Siagian, Forman Erwin
Description Malaria is amongst the most prevalent and epidemiologically relevant global parasitic protozoan infections. It is infecting millions of people annually, especially in south east Asia and sub Saharan Africa. Its morbidity and mortality still cannot be controlled entirely and elimination is still far away. Children and pregnant women are among the most vulnerable group in the population. Its pathobiology have related to cause direct or indirect deleterious effect on the patient’s skeletal muscle, named rhabdomyolysis. Eventhough it is very rare, but potentially fatal and lethal. Three mechanism of malaria related rhabdomyolysis are very intense inflammatory response, extensive red cells sequestration in muscle capillaries due to severe anemia and the parasite toxin’s, will  lead to or add risks of complication. Derangement of specific type of muscle, named the skeletal and cardiac, is amongst the earliest sign of severe malaria. Further study need to be conducted in the future, especially on important topics about mechanism and its effect, signaling pathways, best practice on laboratory approach and management strategy best practice.
Publisher International Journal of Pathogen Research
Date 2020-11-20
Type info:eu-repo/semantics/article
Format application/pdf
Source International Journal of Pathogen Research; 2020 - Volume 5 [Issue 3]; 39-51
Language eng
Rights Copyright (c) 2020 © 2020 Siagian; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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