Multiple Injection of Human Wharton’s Jelly Mesenchymal Stem Cells Ameliorate Spermatogenic Cells on Physiological Aging Male Rats

Journal of Stem Cell Research and Tissue Engineering

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Field Value
 
Title Multiple Injection of Human Wharton’s Jelly Mesenchymal Stem Cells Ameliorate Spermatogenic Cells on Physiological Aging Male Rats
 
Creator fitrianto, alif imam
 
Subject stem cell, tissue engineering
Keywords: aging, Leydig cells, spermatogonia, stem cells
 
Description Recently, the most common therapy on men who suffered fertility decline due to aging was testosterone replacement, but now it is known that this therapy has a long-term risk of damage to the cardiovascular system and prostate. Stem cells are an alternative therapy that has a potency to improve the fertility of aging men that less causing side effects. The aim of this study was to evaluate the injection of Human Wharton’s Jelly Mesenchymal Stem Cells (hWJ-MSC) in physiologic aging male rats on spermatogenic cells. This study used 3 young male rats (8-12 weeks) and 6 physiological aging rats (22-24 months) which divided into 3 groups, the young rat group did not give any treatment, physiological aging male rats received NaCl (0.9%) 0.4 mL, and physiological aging male rats received 1x106 cells/kg BW of hWJ-MSCs. The observations were performed on histological analysis. The results indicate that the hWJ-MSCs injections increased the number of spermatogonia and Leydig cells significantly (P<0.05), and improve the tubules circumference and interstitial area significantly (P<0.05). The mechanism of spermatogenic cells repairs suspected due to various bioactive molecules that secreted by hWJ-MSCs which can affect the surrounding cells. 
 
Publisher Stem Cell Research and Development Center, Universitas Airlangga
 
Contributor
 
Date 2019-12-11
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://e-journal.unair.ac.id/JSCRTE/article/view/16323
10.20473/jscrte.v3i1.16323
 
Source Journal of Stem Cell Research and Tissue Engineering; Vol 3, No 1 (2019): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING; 1-5
2614-1256
2614-1264
 
Language eng
 
Relation https://e-journal.unair.ac.id/JSCRTE/article/view/16323/8980
https://e-journal.unair.ac.id/JSCRTE/article/downloadSuppFile/16323/4009
 
Rights Copyright (c) 2019 Journal of Stem Cell Research and Tissue Engineering
http://creativecommons.org/licenses/by-nc-sa/4.0
 

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