Effect of Aerobic Exercise on Brain-derived Neurotrophic Factor (BDNF) Serum Level in Stroke Subjects with Cognitive Function Impairment

Surabaya Physical Medicine and Rehabilitation Journal

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Title Effect of Aerobic Exercise on Brain-derived Neurotrophic Factor (BDNF) Serum Level in Stroke Subjects with Cognitive Function Impairment
 
Creator Aisyah, Vanydia
Subagyo, Subagyo
Subadi, Imam
 
Subject Physical Medicine and Rehabilitation
aerobic exercise; cognitive function impairment; serum brain-derived neutrophic factor; BDNF; static cycle; stroke
 
Description Background: Cognitive impairment is the most frequent complication of stroke. However, erobic exercise is considered to have potential effect in inhibiting the post-stroke cognitive degradation and increasing cognitive performance through neuroplasticity-influenced long term potentiation in hippocampus.Aim: To determine the effect of aerobic exercise on brain-derived neurotrophic factor (BDNF) serum level in stroke subjects with cognitive function impairment.Material and Methods: Experimental pre-post study on sub-acute stroke male and female, 12 subjects on each group. Intervention group given standard therapy and aerobic exercise using static cycle. Control group treated with standard therapy 30 minutes/session 3x/week, for 6 weeks. Parameter being evaluated was BDNF serum level.Result: No significant difference (p=0.21) in BDNF serum level in both control group (246.03±40.81 pg/ml) and intervention group (280.98±73.53 pg/ml) after treated with treatment. Although there was a significant increase of BDNF serum level in the intervention group (p<0.001) with pre-intervention mean value of 1.96±60.69 pg/ml and post-intervention mean value of 280.98±73.53 pg/ml. Similar to the intervention group, there was a significant increase in BDNF serum level (p<0,001) in control group, with pre-intervention mean value of 136.39±76.32 pg/ml and post-intervention mean value of 246.03±40.81 pg/ml.Conclusion: No significant difference in BDNF serum levels in intervention group after aerobic exercise program with a static cycle and standard therapy 3x/week for 6 weeks, when compared to the control group that only received standard therapy, although both control and intervention groups showed significant difference before and after the intervention.
 
Publisher FK Universitas Airlangga
 
Contributor
 
Date 2020-08-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://e-journal.unair.ac.id/SPMRJ/article/view/17669
10.20473/spmrj.v2i2.17669
 
Source Surabaya Physical Medicine and Rehabilitation Journal; Vol 2, No 2 (2020): SPMRJ, AGUSTUS 2020; 42-48
2656-0895
 
Language eng
 
Relation http://e-journal.unair.ac.id/SPMRJ/article/view/17669/11925
http://e-journal.unair.ac.id/SPMRJ/article/downloadSuppFile/17669/4545
 
Rights Copyright (c) 2020 Surabaya Physical Medicine and Rehabilitation Journal
http://creativecommons.org/licenses/by-nc-sa/4.0
 

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