Adverse Effects of Sub-lethal Doses of Chlorpyrifos on Birth Outcome of Female Wistar Rats

Journal of Applied Life Sciences International

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Title Adverse Effects of Sub-lethal Doses of Chlorpyrifos on Birth Outcome of Female Wistar Rats
Creator Iheanacho, J. U. I.
Onyeka, P. I. K.
Udujih, H. I.
Udujih, O. G.
Dozie, U. W.
Description Chlorpyrifos is a widely used Organophosphorus pesticide for pest control, leading to increased risk for humans and wildlife exposure. The aim of the present study was to determine the effects of chlorpyrifos on birth outcome in pregnant female wistar rats (Rattus novergicus). Animals were randomly assigned into 4 equal groups, group 1 were untreated and served as control. Rats of group 2 to 4 were treated with chlorpyrifos at concentration 0.2%, 0.4% and 0.8% respectively through feed and drinking water ad libitum from gestation day 1 through to weaning. The results on litter size indicates non-significant dose dependent decrease (p>0.05) across treated groups. Total litter birth weight significantly decreased (p<0.05) in a dose dependent manner compared with control. Stillbirth recorded non-significant (p>0.05) among treatment groups when compared with that of control. Also, postnatal survival showed significant (p<0.05) dose dependent lower number of pups survival between parturition and weaning. These results demonstrated that Chlorpyrifos has adverse impact on birth outcome in treated rats.
Publisher SCIENCEDOMAIN international
Date 2020-08-27
Type info:eu-repo/semantics/article
Format application/pdf
Source Journal of Applied Life Sciences International; 2020 - Volume 23 [Issue 8]; 1-6
Language eng
Rights Copyright (c) 2020 Iheanacho et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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