Prion Interaction with Normal Protein in Topological Changing Secondary Structure to Aggregation

Advanced Emergency Medicine

View Publication Info
 
 
Field Value
 
Title Prion Interaction with Normal Protein in Topological Changing Secondary Structure to Aggregation
 
Creator Yao, Yao
 
Subject Prion; α-helix; β-sheet; Hydrogen Bond; Aggregation
 
Description Prion is a protein smaller than virus and it infects host in the absence of nucleic acid. The secondary structure of protein folds incorrectly from α-helices to β-sheets through breaking and re-formation of hydrogen bond. Structural analogy of α-helix and DNA double helix and comparing differences between α-helix and β-sheet show prion's infectivity and propagation. Aggregates of dimers and polymers generate β-amyloid fibril in Alzheimer's disease.
 
Publisher Universe Scientific Publishing Pte. Ltd.
 
Contributor
 
Date 2020-06-25
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://aem.usp-pl.com/index.php/aem/article/view/167
10.18686/aem.v9i2.167
 
Source Advanced Emergency Medicine; Vol 9, No 2 (Published); 53-56
2315-456X
 
Language eng
 
Relation http://aem.usp-pl.com/index.php/aem/article/view/167/163
 
Rights Copyright (c) 2020 Yao Yao
http://creativecommons.org/licenses/by-nc/4.0
 

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