Management of Severe Beta-Blockers Toxicity with High Dose Insulin Euglycemic Therapy: A Case Report

International Journal of Medical and Pharmaceutical Case Reports

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Field Value
 
Title Management of Severe Beta-Blockers Toxicity with High Dose Insulin Euglycemic Therapy: A Case Report
 
Creator Hussein, K.
Neill, A.
Galvin, S.
 
Description Aims: Highlighting the efficacy of early initiation of high dose insulin therapy in Beta-blockers overdose over conventional therapy.
Presentation of Case: Authors describe the successful treatment of severe bisoprolol-induced cardiogenic shock in a 74-year-old man using high dose insulin euglycemic therapy. He received intravenous bolus of 1IU/kg of actarapid insulin followed by intravenous infusion of 0.5 IU/kg/hour. The patient hemodynamic parameters improved dramatically within few hours after starting the insulin therapy.
Discussion: Beta-blockers overdose can lead to significant morbidity and mortality due to the often-associated vasopressor-resistant shock. high dose insulin euglycemic therapy is a potential emerging therapy for beta-blockers toxicity with support in the literature from several animal studies, case reports and expert opinion.
Conclusion: High dose insulin euglycemic therapy is a safe and effective method in reversing the hemodynamic consequences induced by beta-blockers overdose and should be used early in the treatment.
 
Publisher SCIENCEDOMAIN international
 
Date 2020-07-13
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier http://journalijmpcr.com/index.php/IJMPCR/article/view/30113
10.9734/ijmpcr/2020/v13i130113
 
Source International Journal of Medical and Pharmaceutical Case Reports; 2020 - Volume 13 [Issue 1]; 24-28
2394-109X
 
Language eng
 
Relation http://journalijmpcr.com/index.php/IJMPCR/article/view/30113/56500
http://journalijmpcr.com/index.php/IJMPCR/article/view/30113/56501
 
Rights Copyright (c) 2020 © 2020 Hussein et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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