Formulate and evaluate once daily sustained release tablet of highly soluble drug of metformin HCL

International Journal of Research in Pharmaceutical Sciences and Technology

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Field Value
 
Title Formulate and evaluate once daily sustained release tablet of highly soluble drug of metformin HCL
 
Creator Manalan, B. Valli
Nadendla Swathi
Narra Nandini
N. Hari Sree
Nilla Tejaswi Sai Maha Lakshmi
Mohammed Afrin Roshanara
Rama Rao Nadendla
 
Subject HPMC K 200M
hydrophilic polymer
Metformin Hcl
Matrix tables
 
Description The aim of the present study was to design an oral sustained release matrix tablet of highly water soluble biguanide anti diabetic drug. The matrix tablets are prepared by melt granulation method using HPMC K 200M as hydrophilic drug release retarding polymer, and stearic acid as melt able binder as well as hydrophobic carrier. The drug and excipients compatibility was studied by FT – IR. The formulated matrix tablets were characterized for physical parameters and in vitro dissolution profile. FT – IR spectra revealed the absence of drug excipients interaction. The physical parameters of the tablets were found within the limits. The drug release kinetics demonstrated that by increasing the concentration of hydrophilic polymer and hydrophobic carrier the drug release rate was retarded proportionally. Kinetic modelling of in vitro release profile revealing that the drug release from the matrix tablets following first order kinetics, and the drug release mechanism of optimized (F7) formula following non fickian transport mechanism. Accelerated stability studies were performed according to ICH guide lines. Temperature 40±20 c and relative humidity 75±5% RH to study physical and chemical changes of formulation. No physical or chemical changes were observed after t accelerated stability studies.
 
Publisher Rubatosis Publications
 
Date 2020-07-14
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://rubatosis.org/journals/index.php/ijrpst/article/view/206
10.33974/ijrpst.v1i4.206
 
Source International Journal of Research in Pharmaceutical Sciences and Technology; Vol 1 No 4 (2020): Volume 1 Issue 4; 138-145
2581-9143
 
Language eng
 
Relation https://rubatosis.org/journals/index.php/ijrpst/article/view/206/114
 
Rights Copyright (c) 2020 B. Valli Manalan
https://creativecommons.org/licenses/by-nc-sa/4.0
 

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