Immunophenotyping for Diagnosis of Oral Lesions: Is It an Important Tool?

International Journal of Medical and Pharmaceutical Case Reports

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Title Immunophenotyping for Diagnosis of Oral Lesions: Is It an Important Tool?
Creator Camargo, Alessandra Rodrigues de
Duarte, Bruna Fischer
Lisboa, Mariah Luz
Cardoso, Chandra Chiappin
Munhoz, Etiene de Andrade
Vieira, Daniella Serafin Couto
Moral, Joanita Angela Gonzaga Del
Silva, Maria Cláudia Santos-
Grando, Liliane Janete
Description Aims: To report two cases of onco-hematologic diseases diagnosed by oral biopsy and subsequent flow cytometry immunophenotyping.
Presentation of Case: Case 1: A 36-year-old woman, HIV +, referred to the Hospital Dentistry Center presenting an extensive, ulcerated and painless lesion in the left maxilla involving teeth #24, #25, #26 and #27. A fine needle aspiration and incisional biopsy were performed and one sample was sent to anatomopathological analysis and other to immunophenotyping. Immunophenotyping revealed 31.2% of aberrant plasma cells with phenotype suggestive of plasmablastic lymphoma.
Case 2: 62-year-old male patient attended Hospital Emergency presenting extra and intraoral swelling on the left side of maxilla. Fine needle aspiration and incisional biopsy were performed, followed by pathological analysis and immunophenotyping. Immunophenotyping revealed 40.7% of large mature B cells with phenotype suggestive of diffuse large B-cell lymphoma. Both patients presented histopathological and immunophenotyping results leading to the same diagnosis. After definitive diagnosis, both patients underwent antineoplastic treatment through cycle of chemotherapy.
Conclusion: Immunophenotyping is a well-established method for the diagnosis of onco-hematologic diseases and has been shown to be effective for the rapid diagnosis of oral tumors.
Publisher SCIENCEDOMAIN international
Date 2020-06-30
Type info:eu-repo/semantics/article
Format application/pdf
Source International Journal of Medical and Pharmaceutical Case Reports; 2020 - Volume 13 [Issue 1]; 16-23
Language eng
Rights Copyright (c) 2020 © 2020 Camargo et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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