Formulation and evaluation of matrix tablets of Eperisone hydrochloride

International Journal of Research in Pharmaceutical Sciences and Technology

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Field Value
 
Title Formulation and evaluation of matrix tablets of Eperisone hydrochloride
 
Creator Peruboina Neelima
Maddula Venkata Ramana
 
Subject Eperisone Hydrochloride
HPMC K100M
EC
PVP K30
in vitro drug release
 
Description The aim of the present research is to develop and optimize Eperisone Hydrochloride extended release matrix tablets. Eperisone Hydrochloride is an antispasmodic drug mainly used to relieve pains it acts by relaxing the skeletal and smooth vascular muscles by blocking spinal reflexes drug which has oral bioavailability of 70% due to hepatic metabolism. Sustained release matrix tablets of Eperisone Hydrochloride were prepared through wet granulation technique by using HPMC K4M and EC as polymers, PVPK30 as binder, Magnesium stearate as lubricant and Talc as glidant. The granules of different formulations were determined for pre compression parameters. The prepared granules along with the excipients were then compressed. The formulated tablets were evaluated for physical characteristics viz. Hardness, Thickness, % Weight variation, Friability and the drug content. Furthermore the tablets evaluated for the in vitro release studies. Out of all the 8 formulations F7 showed desired characteristics in the physical parameters and in vitro drug release of 85.48% in 12hrs.The F7 dissolution data was best fitted to the Zero order model. The prepared Eperisone Hydrochloride matrix tablets found to be having a potential extended drug release.
 
Publisher Rubatosis Publications
 
Date 2020-07-05
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Identifier https://rubatosis.org/journals/index.php/ijrpst/article/view/203
10.33974/ijrpst.v1i4.203
 
Source International Journal of Research in Pharmaceutical Sciences and Technology; Vol 1 No 4 (2020): Volume 1 Issue 4; 131-136
2581-9143
 
Language eng
 
Relation https://rubatosis.org/journals/index.php/ijrpst/article/view/203/113
 
Rights Copyright (c) 2020 Peruboina Neelima, Maddula Venkata Ramana
https://creativecommons.org/licenses/by-nc-sa/4.0
 

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