Green Synthesis of Zinc Oxide Nanoparticles via Algal Route and its Action on Cancerous Cells and Pathogenic Microbes

Advanced Nano Research

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Title Green Synthesis of Zinc Oxide Nanoparticles via Algal Route and its Action on Cancerous Cells and Pathogenic Microbes
Creator Bhattacharya, Priyankari
Chatterjee, Kasturi
Swarnakar, Snehasikta
Banerjee, Sathi
Subject ZnO NPs
green synthesis
melanoma cells
destruction of tumor cells
Description Application of metal oxide nanoparticles for treatment of melanoma cells and microbes is being investigated. Zinc oxide nanoparticles (ZnO NPs) deserve special mention where particles cause destruction of melanoma cells with minimal damage to healthy cells. In the present study, pure phase ZnO NPs with particle size of 3.1 nm were synthesized by green route using algal extract. Skin melanoma (B16F10) cells were treated with synthesized ZnO NP and compared with commercial ZnO NPs and analysed for ED50 for cellular viability using 3% (w/v) of the doses. Sensitivity of B16F10 cells towards green synthesized ZnO NP was found to be more than commercial ZnO NPs. Results showed greater reduction in viability of cells exposed to green synthesized ZnO NPs and with increasing dose of the ZnO NPs, percentage viability of cells gradually reduced. 50% decrease in cellular viability (ED50) was obtained for green synthesized ZnO NP at 3% dose while commercial ZnO exhibited ED50 at 6% of doses. The ZnO NP also showed antimicrobial activity against Pseudomonas sp. and Staphylococcus sp. Zone of inhibition (ZOI) exhibited by Pseudomonas aeruginosa and Staphylococcus aureus for disc diffusion and well diffusion assay was around 10-22 mm and 9-12mm respectively.
Publisher AIJR Publisher
Date 2020-07-05
Type info:eu-repo/semantics/article
Research Articles
Format application/pdf
Source Advanced Nano Research; Vol. 3 No. 1 (2020): in progress...........; 15-27
Language eng
Rights Copyright (c) 2020 Priyankari Bhattacharya, Kasturi Chatterjee, Snehasikta Swarnakar, Sathi Banerjee

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