Antihyperuricemia Activity of Nettle Plant Extract (Urtica dioca L.) in Mice

Health Information : Jurnal Penelitian

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Title Antihyperuricemia Activity of Nettle Plant Extract (Urtica dioca L.) in Mice
Aktivitas Antihiperurisemia Ekstrak Tanaman Jelatang (Urtica dioca L.) pada Mencit
 
Creator Fadilah, Nitya Nurul
Susanti, Susanti
 
Subject Allopurinol
Gout
Hyperuricemia
Jelatang
Allopurinol
Asam urat
Hiperurisemia
Jelatang
 
Description Hyperuricemia is a high level of uric acid in the blood and can cause gout. One of the drugs used to treat hyperuricemia is allopurinol. The use of these drugs can cause various side effects if used for a long period of time. Nettle plants are known to contain flavonoids which can reduce uric acid levels in the blood. This study was conducted to test the activity of nettle plants and to find out the effective dose in reducing blood uric acid levels in mice. In this study, extracts were made using maceration method using 70% ethanol. Tests were carried out on mice induced by pottasium oxonate and chicken liver juice to increase uric acid levels. Then the test animals were divided into 5 groups cosisted of the negative control group (0.5% NaCMC), positive control (allopurinol 13mg/kgBW), the dose I group (125mg/kgBW), dose II (250mg/kgBW), and dose III (500mg/kgBW). Next step is to measured the decrease of uric acid levels in mice’s blood every hour for 5 hours. Then the data of decreased in uric acid levels were processed statistically using the Anova and Duncan method. Based on the results of test in mice, nettle extract has antihyperuricemia activity with successive doses of 500 mg/kgBW (89.91%), 250 mg/kgBW (73.7%), and 125mg/kgBW (63.56%).
Hiperurisemia merupakan tingginya kadar asam urat dalam darah dan dapat menimbulkan penyakit gout. Salah satu obat yang digunakan untuk mengatasi hiperurisemia adalah allopurinol. Penggunaan obat tersebut menimbulkan berbagai efek samping jika digunakan dalam jangka waktu yang lama. Tumbuhan jelatang diketahui mengandung flavonoid yang dapat menurunkan kadar asam urat dalam darah. Studi ini dilakukan untuk menguji aktivitas tanaman jelatang dan untuk mengetahui dosis efektifnya dalam menurunkan kadar asam urat dalam darah pada mencit. Pada penelitian ini, ekstrak dibuat dengan menggunakan metode maserasi menggunakan etanol 70%. Uji dilakukan pada mencit yang diinduksi kalium oksonat dan jus hati ayam agar menaikkan kadar asam uratnya. Kemudian hewan uji dibagi menjadi 5 kelompok yakni terdiri dari kelompok kontrol negatif (NaCMC 0,5%BB), kontrol positif (allopurinol 13mg/kgBB), kelompok dosis I (125mg/kgBB), dosis II (250mg/kgBB), dan dosis III (500mg/kgBB). Selanjutnya diukur penurunan kadar asam urat darah mencit pada tiap jam selama 5 jam. Kemudian data penurunan kadar asam urat diolah secara statistik menggunakan metode Anova dan Duncan. Berdasarkan hasil uji pada mencit, ekstrak jelatang memiliki aktivitas antihiperurisemia dengan dosis berturut-turut adalah 500mg/kg BB (89,91%), 250mg/kg BB (73,7%), dan 125 mg/kg BB (63,56%).
 
Publisher Poltekkes Kemenkes Kendari
 
Date 2021-04-13
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-Reviewed Article
Artikel Reviu Komunitas
 
Format application/pdf
 
Identifier http://myjurnal.poltekkes-kdi.ac.id/index.php/HIJP/article/view/193
10.36990/hijp.vi.193
 
Source Health Information : Jurnal Penelitian; Vol. 12 No. 1 (2020): Januari-Juni; 99-106
Health Information : Jurnal Penelitian; Vol 12 No 1 (2020): Januari-Juni; 99-106
2622-5905
2085-0840
10.36990/hijp.v12i1
 
Language ind
 
Relation http://myjurnal.poltekkes-kdi.ac.id/index.php/HIJP/article/view/193/157
 
Rights Hak Cipta (c) 2020 Nitya Nurul Fadilah, Susanti
https://creativecommons.org/licenses/by-sa/4.0
 

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