Testing of Analgesic Content of Red Flesh Guava Leaf Infusion in Male Mice using Chemical Stimulation Method

Health Information : Jurnal Penelitian

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Title Testing of Analgesic Content of Red Flesh Guava Leaf Infusion in Male Mice using Chemical Stimulation Method
Uji Analgetik Infus Daun Jambu Biji Berdaging Merah pada Mencit Jantan dengan Metode Rangsangan Kimia
 
Creator Prambudi, Hery
 
Subject Analgesic
Chemical stimulation method
Male mice
Red fleshly guava leaves
Analgetik
Daun jambu biji berdaging merah
Mencit jantan
Metode rangsangan kimia
 
Description The flavonoids content on guava leaves has a role to improve blood circulation throughout the body and prevent the occurrence of blood vessel blockage, anti-inflammatory and analgesic. This study aims to determine whether the infusion of red fleshy guava leaves (Psidium guajava Linn.) has an analgesic effect on male mice (Mus musculus) and at what concentration the infusion of red fleshy guava leaves (Psidium guajava Linn.) has an analgesic effect on male mice (Mus musculus). The experiments were carried out using chemical stimulation methods. Analgesics or painkillers are substances that reduce or eliminate pain without losing consciousness (the difference with general anesthesia). This research is a pure experimental study using 25 mice divided into 5 treatment groups, each group consisting of 5 mice, then induced with 1% v / v acetic acid dose 50 mg / kgBB intraperitonially (ip) as pain induction, left for 15 minutes. then the treatment was carried out in each concentration group of 10% w / v, 15% w / v, and 20% w / v. Oral administration of 1% paracetamol suspension solution at a dose of 65 mg / kgBW was used as a positive control, and aquadest was used as a negative control. observations were made by counting the amount of writhing seen in 5 minutes for 60 minutes, then determined the percentage of analgesic power. The results showed that the infusion of red fleshy guava leaves (Psidium guajava Linn.) had an analgesic effect of the percentage of analgesic power of 87.88% which was close to the percentage of paracetamol analgesic power of 100%.
Kandungan flavonoid pada Daun jambu biji berperan untuk melancarkan peredaran darah ke seluruh tubuh dan mencegah terjadinya penyumbatan pembuluh darah, antiinflamasi dan analgetik. Tujuan penelitian ini mengetahui efek analgetik dan pada konsentrasi berapa efek analgetik tersebut pada infus daun jambu biji merah  mencit jantan dengan metode rangsangan kimia Jenis penelitian ini eksperimen murni menggunakan 25 ekor mencit yang dibagi menjadi 5 kelompok perlakuan, tiap kelompok terdiri dari 5 ekor, kemudian diinduksi dengan asam asetat 1%v/v dosis 50 mg/kgBB secara intraperitonial (i.p) sebagai induksi nyeri atau sakit, dibiarkan selama 15 menit. Lalu dilakukan perlakuan pada masing-masing kelompok konsentrasi 10%b/v, 15%b/v, dan 20%b/v.  Kemudian digunakan larutan suspensi parasetamol 1% dosis 65 mg/kgBB sebagai kontrol positif, aquadest sebagai kontrol negatif diberikan secara oral. Diamati jumlah geliat yang timbul dalam 5 menit selama 1 jam, lalu ditentukan persentase daya analgetiknya.  Hasil penelitian menunjukkan bahwa infus daun jambu biji merah, memiliki efek analgetik hasil persentase daya analgetik sebesar 87,88% yang mendekati persentase daya analgetik parasetamol sebesar 100%.
 
Publisher Poltekkes Kemenkes Kendari
 
Date 2021-04-13
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-Reviewed Article
Artikel Reviu Komunitas
 
Format application/pdf
 
Identifier http://myjurnal.poltekkes-kdi.ac.id/index.php/HIJP/article/view/168
10.36990/hijp.vi.168
 
Source Health Information : Jurnal Penelitian; Vol. 12 No. 1 (2020): Januari-Juni; 76-85
Health Information : Jurnal Penelitian; Vol 12 No 1 (2020): Januari-Juni; 76-85
2622-5905
2085-0840
10.36990/hijp.v12i1
 
Language ind
 
Relation http://myjurnal.poltekkes-kdi.ac.id/index.php/HIJP/article/view/168/155
 
Rights Hak Cipta (c) 2020 Hery Prambudi
https://creativecommons.org/licenses/by-sa/4.0
 

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