EVALUATION OF INFLAMMATION AND ENDOTHELIAL DYSFUNCTION BIOMARKERS IN CHRONIC KIDNEY DISEASE (CKD) PATIENTS IN SOKOTO, NIGERIA

Open Journal of Medical Research

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Field Value
 
Title EVALUATION OF INFLAMMATION AND ENDOTHELIAL DYSFUNCTION BIOMARKERS IN CHRONIC KIDNEY DISEASE (CKD) PATIENTS IN SOKOTO, NIGERIA
 
Subject cardiovascular disease
chronic kidney disease
endothelial dysfunction
glomerular filtration rate
inflammation
 
Description Inflammation and endothelial dysfunction have been known to be involved in the pathogenesis of cardiovascular diseases. As such, examining the levels of inflammation and endothelial dysfunction is very critical to the prevention of cardiovascular diseases among chronic kidney disease (CKD) patients. This study aimed to investigate the progression of inflammation and endothelial dysfunction among CKD patients in Sokoto. A total of 67 CKD patients were divided into 5 groups based on the stages of their kidney disease calculated using the MDRD 4-variable equation for estimated glomerular filtration rate (eGFR). The presence of inflammation was determined by C-Reactive Protein (CRP) and Tumor Necrosis Factor alpha, while endothelial dysfunction was determined by the levels of Asymmetric dimethylarginine (ADMA) using ELISA kits. The mean eGFR of the patients was 49.97 ± 4.69 ml/min/1.73m2. There was significant increase (p<0.05) in CRP, TNF-α and ADMA of the CKD patients across the stages as compared to the non-CKD subjects. It was observed that as the CRP, TNF-α and ADMA increase, the eGFR significantly (p<0.05) decreases. Both CRP and TNF-α indicated a significantly positive correlation (p<0.05) with ADMA. The results indicated progressive increase in inflammation and endothelial dysfunction as CKD deteriorates. In addition, increased levels of inflammation could directly affect endothelial dysfunction, thereby aggravating cardiovascular morbidity and mortality among CKD patients in Sokoto.
Otitolaiye, C. A. | Department of Biochemistry, Sokoto State University, Sokoto, Nigeria
 
Publisher Open Journals Nigeria (ON)
 
Date 2020-03-10
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Identifier https://www.openjournalsnigeria.org.ng/journals/index.php/ojmr/article/view/72
 
Source Open Journal of Medical Research (ISSN: 2734-2093) ; Vol. 1 No. 1 (1): OJMR 2020 First Issue ; 1-9
2734-2093
 
Language eng
 
Relation https://www.openjournalsnigeria.org.ng/journals/index.php/ojmr/article/view/72/79
 
Rights Copyright (c) 2020 Otitolaiye et al.
https://creativecommons.org/licenses/by/4.0/
 

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