Association of Myeloid Aberrant Antigens and the Presence of BCR-ABL Gene Re-arrangements in ALL Patients

Haematology Journal of Bangladesh

View Publication Info
Field Value
Title Association of Myeloid Aberrant Antigens and the Presence of BCR-ABL Gene Re-arrangements in ALL Patients
Creator Azam, Md. Shafiul
Islam, Khaza Amirul
Mafruha, Sharmin
Sarwar, Mirza Golam
Shah, Md. Salahuddin
Aziz, Md. Abdul
Subject Acute Lymphoblastic Leukaemia
Description Background: BCR-ABL translocation is the most common genetic abnormality associated with adult Acute Lymphoblastic Leukaemia (ALL) with poor outcome. Objective: The aim of the study was to determine the association of myeloid aberrant antigens and the presence of BCR-ABL gene rearrangements in acute lymphoblastic leukaemia (ALL) patients in our context. Method: A total of 38 ALL patients were included in this cross-sectional study from August 2018 to July 2019 according to selection criteria. BCR-ABL was detected by Real Time-Polymerase Chain Reaction (RT-PCR). Results: The median age at diagnosis was 27.5 years with male (76.3%) predominance. Aberrant myeloid markers, e.g.CD13 was present in 9(64.3%) patients who were BCR-ABL positive which was statistically significant (p:<0.05). Conclusion: Early suspicion about BCR-ABL positivity can be made in ALL patients who show aberrant myeloid expression.
Publisher Haematology Society of Bangladesh
Date 2020-06-20
Type info:eu-repo/semantics/article
Peer-Reviewed Article
Format text/html
Source Haematology Journal of Bangladesh; Vol. 4 No. 1 (2020); 13-15
Language eng
Rights Copyright (c) 2020 Md. Shafiul Azam, Khaza Amirul Islam, Sharmin Mafruha, Mirza Golam Sarwar, Md. Salahuddin Shah, Md. Abdul Aziz

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us


Copyright © 2015-2018 Simon Fraser University Library