Association of Myeloid Aberrant Antigens and the Presence of BCR-ABL Gene Re-arrangements in ALL Patients

Haematology Journal of Bangladesh

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Field Value
 
Title Association of Myeloid Aberrant Antigens and the Presence of BCR-ABL Gene Re-arrangements in ALL Patients
 
Creator Azam, Md. Shafiul
Islam, Khaza Amirul
Mafruha, Sharmin
Sarwar, Mirza Golam
Shah, Md. Salahuddin
Aziz, Md. Abdul
 
Subject Acute Lymphoblastic Leukaemia
BCR-ABL
 
Description Background: BCR-ABL translocation is the most common genetic abnormality associated with adult Acute Lymphoblastic Leukaemia (ALL) with poor outcome. Objective: The aim of the study was to determine the association of myeloid aberrant antigens and the presence of BCR-ABL gene rearrangements in acute lymphoblastic leukaemia (ALL) patients in our context. Method: A total of 38 ALL patients were included in this cross-sectional study from August 2018 to July 2019 according to selection criteria. BCR-ABL was detected by Real Time-Polymerase Chain Reaction (RT-PCR). Results: The median age at diagnosis was 27.5 years with male (76.3%) predominance. Aberrant myeloid markers, e.g.CD13 was present in 9(64.3%) patients who were BCR-ABL positive which was statistically significant (p:<0.05). Conclusion: Early suspicion about BCR-ABL positivity can be made in ALL patients who show aberrant myeloid expression.
 
Publisher Haematology Society of Bangladesh
 
Date 2020-06-20
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-Reviewed Article
 
Format text/html
application/pdf
 
Identifier https://journal.hematologybd.org/index.php/haematoljbd/article/view/60
10.37545/haematoljbd202060
 
Source Haematology Journal of Bangladesh; Vol. 4 No. 1 (2020); 13-15
2707-1405
2523-1219
 
Language eng
 
Relation https://journal.hematologybd.org/index.php/haematoljbd/article/view/60/164
https://journal.hematologybd.org/index.php/haematoljbd/article/view/60/165
 
Rights Copyright (c) 2020 Md. Shafiul Azam, Khaza Amirul Islam, Sharmin Mafruha, Mirza Golam Sarwar, Md. Salahuddin Shah, Md. Abdul Aziz
https://creativecommons.org/licenses/by-nc/4.0
 

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