Association of Myeloid Aberrant Antigens and the Presence of BCR-ABL Gene Re-arrangements in ALL Patients
Haematology Journal of Bangladesh
View Publication Info| Field | Value | |
| Title |
Association of Myeloid Aberrant Antigens and the Presence of BCR-ABL Gene Re-arrangements in ALL Patients
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| Creator |
Azam, Md. Shafiul
Islam, Khaza Amirul Mafruha, Sharmin Sarwar, Mirza Golam Shah, Md. Salahuddin Aziz, Md. Abdul |
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| Subject |
Acute Lymphoblastic Leukaemia
BCR-ABL |
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| Description |
Background: BCR-ABL translocation is the most common genetic abnormality associated with adult Acute Lymphoblastic Leukaemia (ALL) with poor outcome. Objective: The aim of the study was to determine the association of myeloid aberrant antigens and the presence of BCR-ABL gene rearrangements in acute lymphoblastic leukaemia (ALL) patients in our context. Method: A total of 38 ALL patients were included in this cross-sectional study from August 2018 to July 2019 according to selection criteria. BCR-ABL was detected by Real Time-Polymerase Chain Reaction (RT-PCR). Results: The median age at diagnosis was 27.5 years with male (76.3%) predominance. Aberrant myeloid markers, e.g.CD13 was present in 9(64.3%) patients who were BCR-ABL positive which was statistically significant (p:<0.05). Conclusion: Early suspicion about BCR-ABL positivity can be made in ALL patients who show aberrant myeloid expression.
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| Publisher |
Haematology Society of Bangladesh
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| Date |
2020-06-20
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Peer-Reviewed Article |
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| Format |
text/html
application/pdf |
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| Identifier |
https://journal.hematologybd.org/index.php/haematoljbd/article/view/60
10.37545/haematoljbd202060 |
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| Source |
Haematology Journal of Bangladesh; Vol. 4 No. 1 (2020); 13-15
2707-1405 2523-1219 |
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| Language |
eng
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| Relation |
https://journal.hematologybd.org/index.php/haematoljbd/article/view/60/164
https://journal.hematologybd.org/index.php/haematoljbd/article/view/60/165 |
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| Rights |
Copyright (c) 2020 Md. Shafiul Azam, Khaza Amirul Islam, Sharmin Mafruha, Mirza Golam Sarwar, Md. Salahuddin Shah, Md. Abdul Aziz
https://creativecommons.org/licenses/by-nc/4.0 |
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